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吗啡和纳洛酮对豚鼠离体胆囊肌条活动的作用

张万琴, 冯镇沅, 梅懋华

大连医学院生理教研室. 辽宁, 大连

摘要

5种浓度的吗啡对胆囊肌条的自动节律性收缩,均有明显加强作用。阿片受体拮抗剂——纳洛酮可阻断和翻转吗啡对胆囊肌条的作用,说明豚鼠的胆囊壁有阿片受体。乙酰胆碱显著地加强胆囊肌条的收缩,此效应可被阿托品阻断,而且阿托品也使吗啡对胆囊肌条的作用明显减弱。异丙肾上腺素和去甲肾上腺素分别抑制和加强胆囊肌条的运动,前者的效应可被心得宁阻断,后者则被酚妥拉明阻断,但两者的效应均不受纳洛酮的影响。而心得宁和酚妥拉明不影响吗啡对胆囊肌条的作用。该实验似能表明,吗啡对胆囊肌条运动的调节是通过阿片受体而起作用的。

关键词： 胆囊肌条; 吗啡; 纳洛酮翻转; 阿托品

Effects of morphine and naloxone on the motility of the gall bladder muscle strip of the guinea pig

Zhang Wanqin, Feng Zhenyuan, Mei Mahua

Department of Physiology, Dalian Medical College. Dalian, Liaoning, China

Abstract

Experiments were performed in vitro with the gall bladder smooth muscle strip of the guinea pig. It was found that morphine exerted markedly stimulatory effect on the motility of the gall bladder strip. This stimulatory effect was significantly reversed by the specific antagonist of the opiate receptor-naloxone, indicating that the opiate receptors may be present in the gall bladder muscle. Acetylcholine also increases the motility of the gall bladder strip, and this stimulatory effect could be abolished by atropine. Atropine also blocked the effect of morphine on the gall bladder. Isoprenaline could decrease the motility of the strip while norepinephrine could increase it. The former was blocked by practolol, and the latter by phentolamine. Both effects were not influenced by naloxone. Practolol and phentolamine did not influence the effect of morphine on the motility of the gall bladder muscle strip. These results suggest that morphine and its receptor may be involved in the regulation of the motility of the gall bladder, but in this mechanism neither #alpha#-nor #beta#-adrenergic receptors play a role.

Key words: Gall bladder muscle strip;Morphine;Naloxone;Reverse

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引用本文：

张万琴, 冯镇沅, 梅懋华. 吗啡和纳洛酮对豚鼠离体胆囊肌条活动的作用[J]. 生理学报 1985; 37 (2): .

Zhang Wanqin, Feng Zhenyuan, Mei Mahua. Effects of morphine and naloxone on the motility of the gall bladder muscle strip of the guinea pig. Acta Physiol Sin 1985; 37 (2): (in Chinese with English abstract).