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β-内啡肽和强啡肽参与可乐宁和去甲肾上腺素的中枢降压效应

谢翠微, 韩济生

北京医学院生理教研室. 北京

摘要

大鼠侧脑室注射(icv)可乐宁和去甲肾上腺素(NE)引起血压降低和心率减慢。此效应可被α受体阻断剂酚妥拉明对抗。icvβ-内啡肽抗体、强啡肽抗体或大剂量阿片受体阻断剂纳洛酮也可防止可乐宁和 NE 降压效应的出现;而甲啡肽抗体、亮啡肽抗体或小剂量纳洛酮均无拮抗作用。以上结果表明,内源性β-内啡肽和强啡肽参与可乐宁和 NE 脑室注射所引起的降压效应。

关键词： 可乐宁; 去甲肾上腺素; 侧脑室注射; 降压效应; 纳洛酮; β-内啡肽抗体; 强啡肽抗体

#Beta#-endorphin and dynorphin are involved in the central depressor action of clonidine or norepinephrine in rats

Xie Cuiwei, Han Jisheng

Depa,tment of Physiology, Beijing Medical College. Beijing, China

Abstract

Intracerebroventricular injection (icv) of clonidine or norepinephrine (NE) induced significant depressor and bradycardiac responses in rats, which were partly antagonized by icv a-adrenoceptor blocker phentolamine. These responses were found to be blocked by large doses of naloxone (100 #mu#g, icv; 10 mg/kg, iv), but not by small doses(10 #mu#g, icv; 2 mg/kg, iv). Antibodies directed to #beta#-endorphin, dynorphin, met-enkephalin and leu-enkephalin, respectively, were injected icv prior to the administration of clonidine or NE. Significant reversal of the depressor action of clonidine or NE was seen in rats pretreated with #beta#-endorphin or dynorphin antibody, while antibodies against met-enkephalin and leu-enkephalin were not effective. The results imply that an activation of #alpha#-receptor as well. as the release of #beta#-endorphin and dynorphin in the brain are important for mediating the depressor action of icv clonidine or NE.

Key words: Clonidine;Norepinephrine;Intracerebroventricular injection;Depressor action;Naloxone;Beta-endorphin antibody;Dynorphin antibody

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引用本文：

谢翠微, 韩济生. β-内啡肽和强啡肽参与可乐宁和去甲肾上腺素的中枢降压效应[J]. 生理学报 1985; 37 (2): .

Xie Cuiwei, Han Jisheng. #Beta#-endorphin and dynorphin are involved in the central depressor action of clonidine or norepinephrine in rats. Acta Physiol Sin 1985; 37 (2): (in Chinese with English abstract).