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兔脊髓α受体对血量扩张引起肾交感神经活动抑制和促钠排泄的作用

王勇, 林茂樟, 韩桂春

大连医科大学生理教研室. 辽宁, 大连 116027；遵义医学院生理教研室. 遵义 563003

摘要

在窦主动脉去神经麻醉兔观察阻断脊髓α受体对血量扩张引起肾交感神经活动(RSNA)抑制和促钠排泄反应的影响。兔脊髓蛛网膜下腔注射a肾上腺素能受体阻断剂酚妥拉明与人工脑脊液后，血量扩张引起RSNA抑制分别为(-25.4±5.4)％与(-42.5±5.2)％(P＜0.05＝；兔脊髓蛛网膜下腔注射α_(1)受体阻断剂哌唑嗪与人工脑脊液后血量扩张引起RSNA抑制分别为(-29.3±6.1)％与(-42.5±5.2)％(P＜0.05＝。结果表明，阻断脊髓α受体或α1受体均可减弱血量扩张引起RSNA抑制。脊髓注射哌唑嗪后血量扩张引起促钠排泄与利尿反应也显著减弱(P＜0.05＝。

关键词： 脊髓α肾上腺素能受体; 血量扩张; 肾交感神经活动; 促销排泄; 利尿

Role of spinal #alpha# adrenoceptor in the inhibition of renal sympathetic nerve activity and natriuresis induced by blood volume expansion in rabbits

Wang Yong, Lin Maozhang, Han Guichun

Department of Physiology, Dalian Medical University. Dalian 116027, Liaoning, China

Abstract

The effect of spinal #alpha# adrenoceptor blockage on the inhibition of renal sympathetic nerve activity (RSNA) and natriuresis induced by blood volume expansion was investigated in anesthetized and bilateral sinoaortic denervated rabbits. In the groups of rabbits with intrathecal injection of #alpha#-adrenoceptor blocker phentolamine or artificial cerebrospinal fluid the inhibition of RSNA induced by blood volume expansion were (-25.4+-5.4)% and (-42.5+-5.2)% respectively (P<0.05). In the groups of rahbits with intrathecal injection of #alpha#_(1) adtenoceptor blocker prazosin or artificial cerebrospinal fluid the inhibition of RSNA induced by blood volume expansion were (-29.3+-6.1)% and (-42.5+-5.2)% respectively (P<0.05). These results suggested that both spinal #alpha# and #alpha#_(1) adrenceptor blockage attenuated the inhibition of RSNA induced by blood volume expansion.

Key words: Spinal #alpha# adrenceptor;Blood volume expansion;Renal sympathetic nerve activity;Natriuresis;Diuresis

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引用本文：

王勇, 林茂樟, 韩桂春. 兔脊髓α受体对血量扩张引起肾交感神经活动抑制和促钠排泄的作用[J]. 生理学报 1997; 49 (6): .

Wang Yong, Lin Maozhang, Han Guichun. Role of spinal #alpha# adrenoceptor in the inhibition of renal sympathetic nerve activity and natriuresis induced by blood volume expansion in rabbits. Acta Physiol Sin 1997; 49 (6): (in Chinese with English abstract).