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去甲肾上腺素对冷适应大鼠下丘脑脑片视前区温敏神经元的影响

孙久荣, 马永超, 许兆辉, 赵文剑, 蔡益鹏

北京大学生命科学学院生理及生物物理系. 北京 100871

摘要

本工作用离体脑片的方法，观测了去甲肾上腺素(NE)对冷适应大鼠下丘脑视前区(POAH)温敏神经元自发放电活动的影响。结果表明：冷适应大鼠热敏神经元(WS)，冷敏神经元(CS)和非温敏神经元(TI)对NE的敏感性较室温下生活的大鼠显著提高(对NE反应的阈浓度显著降低)；与正常室温组大鼠相比，冷适应大鼠WS中受NE兴奋的神经元比数降低，部分WS出现抑制反应；NE引起抑制反应的CS比数降低，部分CS出现兴奋性反应；而TI中受NE兴奋和抑制的比数皆升高，无反应的神经元比数减少。

关键词： 冷适应; 下丘脑视前区(POAH); 脑片; 温敏神经元; 去甲肾上腺素(NE)

Effect of Norepinephrine on the thermosensitive neurons in preoptic area of hypothalamus tissue slices in cold acclimatized rats

Sun Jiurong, Ma Yongchao, Xu Zhaohui, Zhao Wenjian, Cai Yipeng

College of Life Sciences, Peking University. Beijing 100871, China

Abstract

In this work, single unit firing activities were recorded in the preoptic anterior hypothalamus (POAH) brain slices of cold acclimatized and room-temperature housed rats (CR and RR) and the effects of NE on the neuronal discharges were observed. The neurons of POAH in CR became much more sensitive to NE than that in RR (the threshold concentration of NE of CR became significantly lowered). In comparison with RR, the percentage of warm sensitive neurons that could be excited by NE was decreased and some of them even showed inhibitory responses. On the other hand, the percentage of cold sensitive neurons that could be inhibited by NE was decreased and some of them even showed excitatory responses. The percentage of thermo-insensitive neurons that could be either excited or inhibited by NE were increased.

Key words: Cold adaptation;POAH;Brain slice;Thermosensitive neurons;Norepinephrine

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引用本文：

孙久荣, 马永超, 许兆辉, 赵文剑, 蔡益鹏. 去甲肾上腺素对冷适应大鼠下丘脑脑片视前区温敏神经元的影响 [J]. 生理学报 1997; 49 (6): .

Sun Jiurong, Ma Yongchao, Xu Zhaohui, Zhao Wenjian, Cai Yipeng. Effect of Norepinephrine on the thermosensitive neurons in preoptic area of hypothalamus tissue slices in cold acclimatized rats. Acta Physiol Sin 1997; 49 (6): (in Chinese with English abstract).