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大鼠初级感觉神经外周末梢间信息传递的观察

王军, 王才源, 关新民

同济医科大学神经生物学教研室. 湖北, 武汉 430030；中国科学院上海脑研究所. 上海 200031

摘要

实验切断麻醉大鼠一侧TS～L1脊神经背部皮支的中枢端，用50Hz，0.2ms，总时间为2s的方波逆行刺激其中一皮支的外周端，记录其相邻皮支的电活动。结果发现刺激停止后25s内被记录皮支的放电迅速增加，继而逐渐恢复到刺激前的水平；414个序列实验结果的累积时程分析表明：被记录皮支的放电频率在刺激停止后的第2秒达最大值，并持续3s，从第5秒开始逐渐下降，第25秒及以后恢复到刺激前的水平；放电频率的增加量与刺激前被记录皮支的自发放电频率呈直线正相关，且在一定程度上与刺激序列数相关；相同条件的单脉冲刺激未能在被记录皮支上诱发出放电频率增加或记录到复合动作电位。实验还用夹伤被刺激皮支的方法排除了电流扩散引起相邻皮支放电增加的可能。结果提示：初级感觉神经外周末梢间可以进行化学性信息传递。

关键词： 感觉神经末梢; 信息传递; 大鼠

An observation on the possible existance of some information transmission between sensory nerve endings of rat

Wang Jun, Wang Caiyuan, Guan Xinmin

Department of Neurobiology, Tongji Medical University. Wuhan 430030, Hubei, China

Abstract

Dorsal cutaneous branches of the spinal nerves of T5～L1 segments on one side in anaesthesised rats were exposed and cut centrally. One peripheral end of the cut nerves was selected for antidromical stimulation, while an adjacent one for recording, both by Ag-AgCl electrodes. When a train of 50 Hz, 0.2 ms width square waves of 2 s was delivered to the nerve preparation for stimulation, the discharge of the adjacent nerve showed a remarkable increase and then subsided to the original level for about 25 s. Such experiments (n=414) showed that the induced discharge frequency reached its maximum 2 s after the stimulation and maintained for another 2 s before subsiding to the original level in about a period of 25 s. Using the discharge frequency at a certain time segment as an index, the degree of induced discharges of the recorded nerves were lineary related to their spontaneous discharges before stimulation and the sequences of stimulation to some extent.

Key words: Sensory nerve endings;Information transmission;Rat

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引用本文：

王军, 王才源, 关新民. 大鼠初级感觉神经外周末梢间信息传递的观察[J]. 生理学报 1997; 49 (6): .

Wang Jun, Wang Caiyuan, Guan Xinmin. An observation on the possible existance of some information transmission between sensory nerve endings of rat. Acta Physiol Sin 1997; 49 (6): (in Chinese with English abstract).