过刊浏览

肝部分切除后肝再生增强因子信使核糖核酸(mRNA)表达增强

杨晓明, 谢玲, 吴祖泽, 贺福初

军事医学科学院放射医学研究所. 北京 100850

摘要

肝再生增强因子(ALR)是一种新的肝增殖刺激因子。该研究选择70％肝部分切除(PH)大鼠为模型，观察了PH后残存肝组织胞浆液促肝细胞增殖活性与ALR特异mRNA表达动态变化的关系。发现正常肝组织几无ALRmRNA表达，其肝胞质液也无促肝细胞增殖活性；70％PH后12h肝组织AthmRNA表达明显增加，并于术后24h达高峰，肝胞质液活性也于术后24h内达高峰，这种mRNA表达一效应的时间关系提示：ALR可能是一种重要的生理性肝再生调控因子。

关键词： 肝再生增强因子; mRNA 肝再生; 肝部分切除

Increase in the level of augmenter of liver regeneration mRNA in the rat regenerating liver after partial hepatectomy

Yang Xiaoming, Xie Ling, Wu Zuze, Wu Chutse

Institute of Radiation Medicine, Academy of Military Medical Sciences. Beijing 100850

Abstract

Augmenter of liver regeneration (ALR) is a novel hepatic stimulator. After 70% of the rat liver was removed, ALR-like activity in the remnant liver began to increase within 24 h. In parallel with the activity, the ALR mRNA level in the remnant liver increased 12 h after the operation and reached a maximum in 24 h. These findings indicate that the liver itself produees ALR, which may be a hepatotropic factor acting as a trigger for liver regeneration.

Key words: Augmenter of liver regeneration;mRNA;Liver regeneration

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

杨晓明, 谢玲, 吴祖泽, 贺福初. 肝部分切除后肝再生增强因子信使核糖核酸(mRNA)表达增强[J]. 生理学报 1997; 49 (5): .

Yang Xiaoming, Xie Ling, Wu Zuze, Wu Chutse. Increase in the level of augmenter of liver regeneration mRNA in the rat regenerating liver after partial hepatectomy. Acta Physiol Sin 1997; 49 (5): (in Chinese with English abstract).