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猫颈动脉区压力和化学感受性刺激对巨细胞旁外侧核单位放电的影响

骆鸿, 何瑞荣

河北医学院基础医学研究所生理研究室. 河北

摘要

在31只氯醛糖和氨基甲酸乙酯麻醉的猫,观察了选择性激活颈动脉压力和化学感受器对巨细胞旁外侧核(PGL)单位放电的影响。136个PGL自发放电单位中,有84个在激活颈动脉压力感受器(BA)(新福林,1-2μg/kg,iv)和/或激活颈动脉化学感受器(CA)(nicotine 5-20μg,溶于0.25-0.5ml生理盐水中,注入甲状腺动脉)时,放电频率有变化。在这些有反应的单位中,16个仅对CA起反应(11个兴奋、5个抑制);54个以各种组合方式对CA和BA都起反应,其中以CA引起兴奋反应而BA引起抑制反应的占比例最大;14个仅对BA起反应(7个兴奋,7个抑制)。

关键词： 颈动脉化学感受器; 颈动脉压力感受器; 巨细胞旁外侧核; 单位放电; 延髓腹外侧部

Effects of carotid baro-and chemoreceptor stimulation on the single unit activity of nucleus paragigantocellularis lateralis

Luo Hong, Ho Shiuyong

Department of Physiology, Institute of Basic Medicine, Hebei Medical College. Hebei, China

Abstract

The effects of selective activation of carotid baro- and chemoreceptor on the
single unit activity of the nucleus paragigantocellularis lateralis (PGL) in ventrolateral medulla were studied in 31 cats under #alpha#-chloralose and urethan anesthesia. Of the 136 units with spontaneous discharge in the PGL, 84 showed some change of discharge frequency in response to the activation of carotid baroreceptor (phenylephrine, 1-2/#mu#g/kg iv) (BA) and/or chemoreceptor nicotine, 5-20#mu#g, injected into the thyroid artery) (CA). Of these 84 units, 16 responded only to CA (11 excited and 5 inhibited), 54 responded with various patterns to both CA and BA,in which majority of the units were excited by CA and inhibited by BA, and 14 responded only to BA (7 excited, 7 nhibited). Topographically, the units responsive only to CA were primarily located in the ventral part of the PG L, the units responsive only to BA located dorsally, and the units responsive both to BA and CA located in the middle or more dorsal part of the PGL. These results showed that the informations from carotid baro-and chemoreceptor were conveyed to P GL and converged on some neurones. In all responsive units of the PGL, 68 responded to baroreceptor activation, in which 29 were excited and 39 were inhibited (P j0.05), and 70 responded to chemoreceptor activation, in which 48 were excited and 22 were inhibited (P<0.005).These results suggested that the neurones in PGL were either activated or inactivated by BA, but mainly activated by CA.

Key words: Carotid chemoreceptor;Carotid baroreceptor;Nucleus paragigantocellularia lateralis;Single unit discharge;Ventrolateral medulla

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引用本文：

骆鸿, 何瑞荣. 猫颈动脉区压力和化学感受性刺激对巨细胞旁外侧核单位放电的影响[J]. 生理学报 1987; 39 (5): .

Luo Hong, Ho Shiuyong. Effects of carotid baro-and chemoreceptor stimulation on the single unit activity of nucleus paragigantocellularis lateralis. Acta Physiol Sin 1987; 39 (5): (in Chinese with English abstract).