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血浆游离脂肪酸浓度变化与消化间期综合肌电周期的关系

张幼枚, 张经济, 郑天珍

兰州医学院生理学教研室. 兰州

摘要

用狗进行慢性实验,在十二指肠浆膜缝植三对双极电极,记录空腹时的电活动。观察血浆游离脂肪酸(FFA)浓度变化与消化间期综合肌电(IDMEC)周期性活动的关系。实验结果提示:(1)血浆FFA浓度随IDMEC周期不同时相而变动,Ⅰ相时最低,Ⅲ相时最高(P<0.01);(2)静脉注射心得安后,血浆FFA浓度降低,随IDMEC的周期波动消失;(3)静脉注射酚妥拉明后,在IDMEC的各时相中血浆FFA浓度升高,且无周期性波动;(4)切除双侧迷走神经干后,血浆FFA浓度略有降低,随IDMEC的周期波动仍然存在;(5)静脉注射心得安、酚妥拉明和切除迷走神经后,对IDMEC的周期性活动没有明显的影响。

关键词： 消化间期综合肌电; 血浆游离脂肪酸; 心得安; 酚妥拉明; 迷走神经切除

The relationship between change in concentration of plasma free fatty acids and period of interdigestive myoglectric complex

Zhang Youmei, Zhang Jingji, Zheng Tianzhen

Department of Physiology, Lanzhou Medical College. Lanzhou, China

Abstract

The purpose of the present study was to determine the relationship between the changes in the concentration of plasma free fatty acids (FFA) and different
periods of interdigestive myoelectric complex (IDMEC). Chronic experiments were
performed on conscious fasting dogs with implanted three bipolar electrodes on the surface of duodenum to record the intestinal electrical activity. The results were as follows: (1) The FFA varied in each period of IDMEC cycles regularly, being the highest in phase Ⅲ and lowest in phase I of IDMEC (P<0.01). (2) After intravenous injection of propranolol plasma FFA concentration was reduced and the cyclic fluctuations were abolished. (3) After intravenous injection of phetolamine, plasma FFA concentration became higher than that in normal condition and the cyclic fluctuations abolished. (4) In vagotomy, cyclic fluctuation of plasma FFA level persisted after IDMEC cycles. The aforementioned results indicate that in fasting dogs the concentration of plasma FFA changes with different phases of the IDEMC cycle, which is affected by sympathetic nerve activity.

Key words: Interdigestive myoelectric complex (IDMEC);Plasma free fatty acid;Propranolol;Phentoamine;Vagotomy

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引用本文：

张幼枚, 张经济, 郑天珍. 血浆游离脂肪酸浓度变化与消化间期综合肌电周期的关系[J]. 生理学报 1987; 39 (4): .

Zhang Youmei, Zhang Jingji, Zheng Tianzhen. The relationship between change in concentration of plasma free fatty acids and period of interdigestive myoglectric complex. Acta Physiol Sin 1987; 39 (4): (in Chinese with English abstract).