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下丘脑外侧区注射TRH对大鼠胃酸分泌的影响

凌文华, 戴义隆, 李栋生, 葛志恒

南京医学院生理学教研室. 南京

摘要

该文采用连续收集胃腔灌流法,观察下丘脑外侧区(LHA)注射促甲状腺激素释放激素(TRH)对大鼠胃酸分泌的影响,并分析TRH在LHA促进胃酸分泌的作用机制。结果表明:(1)LHA注射TRH(1μg)明显地刺激胃酸分泌;(2)预先向LHA注射酚妥拉明(10μg)、美多心安(5μg)及胃泌素抗体1μl(1:640)并不影响TRH的泌酸作用,如预先向LHA注射阿托品(5μg)则可消除TRH的泌酸效应;(3)垂体摘除及肾上腺切除均不影响TRH的泌酸作用;(4)隔下迷走神经切断后,LHA注入TRH的泌酸效应仍然出现,但持续时间显著缩短;腹腔交感神经节摘除后,TRH仍能促进胃酸分泌,但分泌量少而平稳。

关键词： 促甲状腺激素释放激素; 下丘脑外侧区注射; 酚妥达明; 美多心安

Effect of lateral hypothalamus injection of trh on gastric acid secretion in rats

Ling Wenhua, Dai Yilong, Li Dongsheng, Ge Zhiheng

Department of Physiology, Nanjing Medical College

Abstract

In the present study the results were as follows: (1) Thyrotropin-releasing
hormone (TRH) injected into the lateral hypothalamic area (LHA) increased
gastric acid output significantly; (2) The increase was not affected by central
administration of phentolamine or metoprolol and gastrin antibody, but completely abolished by atropine; (3) Hypophysectomy or adrenalectomy did not affect the gastric acid response to TRH nor vagotomy; (4) The time course of acid secretion, induced by TRH after celiac ganglionectomy did not show a peak response.The aforementioned results indicate that cholinergic M-receptor in LHA is involved in the central mechanism of acid secretion induced by TRH and the
sympathetic nerve and vagus are the possible efferent pathways.

Key words: Thyrotropin-releasing hormone;LHA injection;Phentolamine;Metoprolol

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引用本文：

凌文华, 戴义隆, 李栋生, 葛志恒. 下丘脑外侧区注射TRH对大鼠胃酸分泌的影响[J]. 生理学报 1987; 39 (4): .

Ling Wenhua, Dai Yilong, Li Dongsheng, Ge Zhiheng. Effect of lateral hypothalamus injection of trh on gastric acid secretion in rats. Acta Physiol Sin 1987; 39 (4): (in Chinese with English abstract).