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蓝斑核调制电刺激包钦格复合体引起的吸气抑制效应

张发艳, 李艳春, 熊一琴, 王桂敏, 李勤, 宋刚

山东中医药大学生理教研室. 山东, 济南 250014

摘要

实验选用成年健康家兔,用乌拉坦麻醉,以膈神经放电为指标,观察了电刺激和化学刺激脑桥蓝斑核对延髓包钦格复合体吸气抑制效应的影响.结果观察到:(1)长串电刺激蓝斑核后,在一定时间之内电刺激包钦格复合体所导致的膈神经放电抑制效应明显减弱,与对照组(仅刺激包钦格复合体)相比,抑制程度减弱(28.78±19.49)%。

关键词： 包钦格复合体; 蓝斑核; 调制; 电刺激; 呼吸; 家兔

The locus coeruleus modulates the inspiratory inhibition induced by electrical stimulation of the B(o)tzinger complex

Zhang Fayan, Li Yanchun, Xiong Yiqin, Wang Guimin, Li Qin, Song Gang

Department of Physiology, Shandong University of Traditional Chinese Medicine. Jinan 250014；Institute of Physiology, School of Medicine, Shangdong University. Jinaj 250012, China

Abstract

Experiments were done on urethane anesthetized adult rabbits. Long-train electrical stimulation was delivered to the B?tzinger complex(B?t.C) to observe the changes in the peak amplitude of integrated phrenic nerve activity. Then, a long-train electrical stimulation was delivered to the locus coeruleus(LC) or monosodium glutamate was microinjected into the LC . Within a certain period of time, another long-train electrical stimulation was delivered to the B?t.C to observe the responses of phrenic nerve activity. We investigated whether the LC could modulate the inspiratory inhibition induced by electrical stimulation of the B?t.C. The results are as follows: (1) Within a certain period of time after a long-train electrical stimulation applied at the LC, the inspiratory inhibition produced by electrical stimulation at the B?t.C was significantly attenuated.

Key words: Boetzinger complex;Locus coeruleus;modulation;Respiration;Electrical stimulation;Rabbit

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引用本文：

张发艳, 李艳春, 熊一琴, 王桂敏, 李勤, 宋刚. 蓝斑核调制电刺激包钦格复合体引起的吸气抑制效应[J]. 生理学报 2004; 56 (5): .

Zhang Fayan, Li Yanchun, Xiong Yiqin, Wang Guimin, Li Qin, Song Gang. The locus coeruleus modulates the inspiratory inhibition induced by electrical stimulation of the B(o)tzinger complex. Acta Physiol Sin 2004; 56 (5): (in Chinese with English abstract).