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二氮嗪在长时程心脏低温保存中的作用

郭炜, 沈岳良, 陈莹莹, 胡志斌, 严志焜, 夏强

浙江大学医学院生理教研室. 浙江；浙江省人民医院. 浙江, 杭州 310031

摘要

延长心脏的体外有效保存时间对临床心脏移植具有重要意义.本文旨在研究线粒体ATP敏感性钾通道开放剂二氮嗪(diazoxide,DE)在离体大鼠心脏长时程低温保存中的作用.SD大鼠随机分成5组,包括对照组(单纯Celsior保存液),DE组(Celsior液中含15、30或45μmol/L/L的DE)和DE+5-HD组[Celsior液中含30μmol/L的DE和100μmol/L的5-羟基葵酸盐(5-hydroxydecanoate,5-HD)]。

关键词： 二氮嗪; 器官保存; 线粒体; 心脏; 三磷酸腺苷; 钾通道; 缺血

The protective effect of diazoxide on long-term heart preservation

Guo Wei, Shen Yueliang, Chen Yingying, Hu Zhibin, Yan Zhikun, Xia Qiang

Department of Physiology, Zhejiang University School of Medicine；Pelple's Hospital of Zhejiang Province. Hangzhou 310031, China

Abstract

Prolongation of the duration of heart preservation in virto is very important in clinical heart transplantation. Previous studies have shown that mitoxhondrial ATP-sensitive potassium channel [mito K_(ATP)] plays an important role in cardioprotective effect. The purpose of this study was to assess whether the mito K_(ATP) opener diazoxide as an additive to cardioplegia solution could enhance myocardial protecton during long-term hypothermic preservation of the rat heart.

Key words: Diazoxide;Organ preservation;Mitochondria;Heart;Adenosine triphosphate;Potassium channels;Ischemia

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引用本文：

郭炜, 沈岳良, 陈莹莹, 胡志斌, 严志焜, 夏强. 二氮嗪在长时程心脏低温保存中的作用[J]. 生理学报 2004; 56 (5): .

Guo Wei, Shen Yueliang, Chen Yingying, Hu Zhibin, Yan Zhikun, Xia Qiang. The protective effect of diazoxide on long-term heart preservation. Acta Physiol Sin 2004; 56 (5): (in Chinese with English abstract).