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缺氧诱导因子-1α在缺氧预处理预防心肌细胞损伤中的作用

徐菲菲, 刘秀华, 蔡莉蓉

中国人民解放军总医院基础医学研究所病理生理研究室. 北京 100853

摘要

本工作旨在研究缺氧预处理(hypoxic preconditioning,HPC)对于心肌细胞外信号调节激酶(extracellular signal-regulatedprotein kinases,ERK)活性、缺氧诱导因子-1α(hypoxia-inducible factor-1α,HIF-1α)表达的影响,及其在缺氧复氧诱导心肌细胞损伤中的作用。

关键词： Hypoxia-inducible factor-1#alpha#; Ischemic preconditioning; Apoptosis; Cardiac myocytes

Role of hypoxia-inducible factor-1α in the prevention of cardiomyocyte injury induced by hypoxic preconditioning

Xu Feifei, Liu Xiuhua, Cai Lirong

Department of Pathophysiology, Chinese PLA General Hospital. Beijing 100853, China

Abstract

In order to understand the intracellular mechanism of preconditionint, we investigated the relationship among activities of extracellular signal-regulated protein kinases (ERKs), the expression of hypoxia-inducible factor-1 #alpha# (HIF-1 #alpha#) and the effect of hypoxic preconditionint (HPC) on the cell injury induced by hypoxia-reoxygenation in cultured neonatal rat cardiomyocytes 24 h after brief hypoxia;

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引用本文：

徐菲菲, 刘秀华, 蔡莉蓉. 缺氧诱导因子-1α在缺氧预处理预防心肌细胞损伤中的作用[J]. 生理学报 2004; 56 (5): .

Xu Feifei, Liu Xiuhua, Cai Lirong. Role of hypoxia-inducible factor-1α in the prevention of cardiomyocyte injury induced by hypoxic preconditioning. Acta Physiol Sin 2004; 56 (5): (in Chinese with English abstract).