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半胱胺对猫脊髓背角神经元伤害性热反应的抑制

杨焕乔, 赵志奇, 刘芸

中国科学院上海脑研究所. 上海 200232

摘要

在戊巴比妥钠麻醉和脊髓腰-1段全横切的16只猫上,观察生长抑素(somatostatin,SOM)的耗竭剂半胱胺对伤害性热刺激脚跖皮肤和电刺激胫后神经所引起的脊髓背角Ⅳ-Ⅵ层神经元单位反应的影响。静脉注射半胱胺50mg/kg对电刺激神经引起的伤害性反应无影响,100mg/kg可使被测试的13个神经元单位中的8个单位反应明显抑制。而静脉注射半胱胺50mg/kg可明显抑制伤害性热刺激所引起的脊髓背角神经元单位反应。用微电极将半胱胺微压注入背角胶质层也使背角神经元的伤害性热反应明显抑制,但只使13个单位中的7个单位对电刺激神经引起的伤害性反应轻度抑制。

关键词： 脊髓背角神经元; 半胱胺; 生长抑素; 伤害性放电反应

Inhibitory effect of cysteamine on nociceptive responses of dorsal horn neurons in spinal cord of cats

Yang Huanqiao, Zhao Zhiqi, Liu Yun

Shanghai Brain Besearch Institute, Chinese Acadmey of Science. Shanghai 200031, China；Shanghai Institute of Physioloyg, Chinese Academy of Sciences. Shanghai 200031, China；Shanghai Medical College for Continuing Education. Shanghai 200232

Abstract

The effect of somatostatin depletor cysteamine on the noeiceptive responses of
neurons in laminae Ⅳ-Ⅵ of spinal cord was studied in 16 pentobarbitone anesthetized and spinal cord transected (at Ll)cats. Intravenous injection of cysteamine. (50 mg/kg) markedly inhibited responses of the neurons produced by noxious heating (50℃) of glabrous skin of the plantar region，but not C fibre responses induced by electrical stimulation of unmyelinated fibers of the tibial nerve. However，C responses in 8/13 neurons tested were significantly inhibited by large dose cysteamine(100 mg/kg). Following micropressure ejection of cysteamine(20 psig) into the substantia gelatinosa where somatostatinontaining fibers terminate，heating responses were significantly
inhibited in all laminae Ⅳ-Ⅵ neurons whereas C responses was only weakly inhibited in 7/13. neurons. The results suggest that depletion of spinal somatostatin may be involved in cysteamine-induced inhibition of spinal nociception. The possible mechanism underlying the stronger cysteamine- induced inhibition of heating response was discussed.

Key words: Spinal dorsal horn neuron;Cysteamine;Somatostatin;Naciceptive response

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引用本文：

杨焕乔, 赵志奇, 刘芸. 半胱胺对猫脊髓背角神经元伤害性热反应的抑制[J]. 生理学报 1993; 45 (1): .

Yang Huanqiao, Zhao Zhiqi, Liu Yun. Inhibitory effect of cysteamine on nociceptive responses of dorsal horn neurons in spinal cord of cats. Acta Physiol Sin 1993; 45 (1): (in Chinese with English abstract).