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蟾蜍离体脊神经节神经元对其外周突与中枢突重复刺激的反应

吕国蔚, 高翠英

首都医学院神经生物学研究室. 北京 100054

摘要

该工作用细胞内记录技术记录了18个蟾蜍离体背根节神经元对其外周突与中枢突刺激的反应。1-2Hz刺激背根和坐骨神经引起的背根节细胞的动作电位参数相同。随着刺激频率增高,30％的细胞对背根和坐骨神经刺激同步地发生动作电位振幅降低、波形分解和脱失;70％的细胞也产生不同程度的变化。背根节细胞对背根和坐骨神经重复刺激不能跟随的频率分别平均为126 Hz和323Hz。结果表明,该工作所记录的背根节细胞为A型神经元,其中枢突的直径小于外周突。对上述变化的可能机制,文中也做了讨论。

关键词： 背根神经节; 背根; 坐骨神经; 重复刺激; 频率跟随; 轴突直径

Responses of toad spinal ganglion neurons to repetitive stimulation of their central and prripheral processes

Lu Guowei, Gao Cuiying

Department of Neurobiology, Capital Institute of Medicine. Beijing 100054, China

Abstract

Intracellular recordings were made from 48 toad dorsal root ganglion neurons mniru while electrical stimulation was delivered respectively to their dorsal root or sciatic nerve input. The average conduction velocities were respectively 12 m/s and 15 m/s. With progressively increasing frequency of stimulation，30% of the recorded cells showed simultaneous decrease of amplitude，wave decomposition and dropping of propagated response to both inputs while 70% of the cells showed more or less different patterns of degradation of the various parameters. Complete failure of neurons to follow the inputs occured respectively at 126 and 323 Hz. Evidently the dorsal root ganglion neurons reported in the present work pertain to type A neuron with central processes smaller in diameter than peripheral ones A possible mechanism underlying the different changes is discussed.

Key words: Dorsal root ganglion;Dorsal root;Sciatic nerve;Repetitive stimulation;Frequency following;Axon diameter

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引用本文：

吕国蔚, 高翠英. 蟾蜍离体脊神经节神经元对其外周突与中枢突重复刺激的反应[J]. 生理学报 1993; 45 (1): .

Lu Guowei, Gao Cuiying. Responses of toad spinal ganglion neurons to repetitive stimulation of their central and prripheral processes. Acta Physiol Sin 1993; 45 (1): (in Chinese with English abstract).