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家兔伏核-杏仁核神经通路在吗啡镇痛中的作用

于龙川, 韩济生

北京医科大学生理教研室. 北京

摘要

用辐射热照射家兔鼻嘴侧部皮肤,测量其躲避反应潜伏期作为痛反应阈,简称痛阈。通过预先埋植的慢性套管向伏核或杏仁核内进行注射,结果表明:(1)在家兔的伏核内微量注射吗啡可产生镇痛作用,该作用可被杏仁核内注射纳洛酮所削弱,并有量效依从关系;在杏仁核内注射甲啡肽抗血清(ME AS)或β-內啡肽抗血清(β-EP AS)亦可削弱上述镇痛作用;(2)在杏仁核内微量注射吗啡可产生镇痛作用,此作用不能被伏核内注射纳洛酮所阻断。

关键词： 伏核; 杏仁核; 吗啡镇痛; 纳洛酮; 阿片肽; γ-氨基丁酸

The neural pathway from nucleus accumbens to amygdala in morphine analgesia of the rabbit

Yu Longcuan, Han Jisheng

Department of Physiology, Beijing Medical University. Beijing, China

Abstract

The purpose of this study was to explore possible neural connections between
the nucleus accumbens and amygdala involved in analgesia. The latency of the escape response elicited by radiant heat applied on snout of the rabbit was taken as an index for nociception. It was found that: (1) the analgesic effect
elicited by intra-accumbens injection of morphine was attenuated dose-dependently by intra-amygdala administration of opioid antagnist naloxone, or antisera against met-enkephalin (ME) or 6-endorphin (,#beta#-EP), suggesting the involvement of ME and ,#beta#-EP in the accumbens-amygdala connection; (2) the analgesia produced by intra-amygdaloid injection of morphine was not affected by naloxone administered to nucleus accumbens, suggesting a one-way connection between the two nuclei; (3) the analgesia of intra-accumbens injection of morphine was significantly attenuated by muscimol, the GABA receptor agonist, and enhanced by bicuculline methochloride, the GABA receptor antagonist injected into the same site where morphine was administered. The results suggest that the analgesic effect of morphine administered to the nucleus accumbens is mediated by the suppression of the GABAergic inhibitory neurons located within the nucleus.

Key words: Nucleus accumbens;Amygdala;Morphin eanalgesia;Opioid peptide;Naloxone;GABA

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引用本文：

于龙川, 韩济生. 家兔伏核-杏仁核神经通路在吗啡镇痛中的作用[J]. 生理学报 1990; 42 (3): .

Yu Longcuan, Han Jisheng. The neural pathway from nucleus accumbens to amygdala in morphine analgesia of the rabbit. Acta Physiol Sin 1990; 42 (3): (in Chinese with English abstract).