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刺激家兔肾内感受器的传入神经活动观察

马戈, 何瑞荣

河北医学院基础医学研究所生理室. 河北

摘要

在44只麻醉家兔观察肾机械和化学感受器刺激对肾传入神经放电活动的影响。结果如下:(1)输尿管压增高20.20±1.09mmHg 引起肾传入神经放电的积分值增加175.13±22.41,(P<0.001)。(2)经输尿管向肾盂内逆向灌注0.15mol/L KCl 和 1mol/L NaCl 溶液时,肾传入神经放电积分值分别增加253.79±21.64%和172.17±15.19%(P<0.001)。(3)肾传入神经纤维的单位放电至少有四种类型:无自发放电活动,自发规则放电,自发规则的猝发放电和不规则放电。(4)输尿管压增高可诱发无自发活动的肾传入神经出现明显的放电,而有自发放电的单位对此种刺激不敏感。

关键词： 肾机械感受器; 肾化学感受器; 输尿管压; 肾传入神经单位放电

Observation on the afferent nerve activity induced by stimulation of renal receptors in the rabbits

Ma Ge, Ho Shiuyong

Department of Physiology, Institute of Basic Medicine, Hebei Medical College. Hebei, China

Abstract

The effects of stimulation of renal mechano-and cheinoreceptors on the afferent renal nerve activity (ARNA) were observed in 44 anesthetized rabbits. The results obtained were as follows:(1) Elevation of ureteral pressure (UP) could induce an increase in integral value of ARNA by 175.13±22.41%(P<0.001). (2) KCl (0.15 mol/L) and NaCl (1 mol/L) perfused retrogradely into pelvis via ureter route resulted in increase of integral value of ARNA by 253.79±21.64% and 172.17±15.19% (P<0.001), respectively. (3) Four patterns of afferent unit discharge were found:no spontaneous activity, regular spontaneous activity, regular spontaneous activity with burst and irregular spontaneous activity. (4) The units of afferent renal nerve with no spontaneous activity were activated markedly by elevation of UP, while the units with spontaneous activity showed no change. (5) In response to the retrograde perfusion of KCl (0.15mol/L) and NaCl(1 mol/L) into pelvis, the activity in units with spontaneous discharge increased markedly by 210.70±23.40% and 140.07±15.72% (P<0.001),respectively, and the other units may be recruited concomitantly. (6) The units with no spontaneous discharge were activated by renal artery occlusion. The results implied that there are mechanoreceptor, Rl and Ra chemoreceptors in the kidney of the rabbit, and they may sense the change in UP, renal ischemia and ionic [K~(+), Na~(+)] concentration of the solute within pelvis.

Key words: Renal mechanoreceptor;Renal chemoreceptor;Ureteral pressure;Unit discharge of afferent renal nerve

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引用本文：

马戈, 何瑞荣. 刺激家兔肾内感受器的传入神经活动观察[J]. 生理学报 1990; 42 (3): .

Ma Ge, Ho Shiuyong. Observation on the afferent nerve activity induced by stimulation of renal receptors in the rabbits. Acta Physiol Sin 1990; 42 (3): (in Chinese with English abstract).