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甲状腺素与甲巯咪唑对大鼠视前区与下丘脑前部温度敏感神经元的影响

王洪琦, 冯甲棣, 姚承禹

广州中医学院内经教研室. 广州；中国医科大学生理教研室

摘要

该文观察了皮下注射甲状腺素和胃饲甲巯咪唑对大鼠视前区-下丘脑前部(PO/AH)温度敏感神经元的影响。PO/AH 存在温度敏感神经元(TSN)和温度不敏感神经元(TIN),在 TSN 中又可分为热敏神经元(WSN)和冷敏神经元(CSN)。在正常大鼠,TSN:TIN=1.43:1;WSN:CSN=1.86:1。以上比例可被甲状腺素和甲巯咪唑所改变:前者使之分别下降为1:2.36和1.20:1;后者使 TSN:TIN 下降为1:1.29,WSN:CSN上升为2.40:1。各组神经元构成比有显著性差异,[X_(2)=9.64,P<0.05]。

关键词： 体温调节; 视前区-下丘脑前部; 温度敏感神经元; 甲状腺激素; 甲巯咪唑

Effects of thyroxine and methimazolum on thermosensitive neurons in preoptic/anterior hypothalamic area in rats

Wang Hongqi, Feng Jiadi, Yao Chengyu

Teaching and Research Section of Neijin, Guangzhou College of Traditional Chinese Medical. Guangzhou, China；Department of Physiology, Chinese Medical University. Shenyang

Abstract

The effects of thyroxine (subcutaneous injection) and methimazolum (intubation feeding) on thermosensitive neurons (TSN) in the preoptic/anterior hypothalamic (PO/AH) area in rats were observed.The ratio of warm-sensitive neurons (WSN) to cold-sensitive neurons (CSN) was 1.86:1 and thermo-insensitive neurons (TIN) to thermosensitive neurons (TSN)1:1.43 in the control group. The ratio of WSN to CSN decreased to 1.20:1 and the ratio of TIN to 1:2.36 in the thyroxine group, while the former increased to 2.40:1 and the latter decressed to 1:1.29 in the methimazolum group. There was significant difference among three groups,[X_(2)=9.64,P<0.05]. Thirty-two percent of neurons (11/34) showed higher firing rates(>15Hz) in the control group, only 8% (3/37) in the thyroxine group and 9% (3/32) in the methimazolum group. In addition, the tolerance of TSN to warming stimulation was obviously lower in both pathological groups, as compared with the control group. The results suggest that a rise or fall of body temperature
in rats with subcutaneous injccting thyroxine and intubation feeding methimazolum may be related to the changes of proportion and excitability of PO/AH neurons, and that the disturbance of thyroxine synthesis, release and metabolism may interfere temperature regulation at the level of hypothalamus.

Key words: Temperature-regulation;Thermosensitive neuron;Preoptic/anteror hypothalamic area;Thyroxine;Methimazolum

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引用本文：

王洪琦, 冯甲棣, 姚承禹. 甲状腺素与甲巯咪唑对大鼠视前区与下丘脑前部温度敏感神经元的影响[J]. 生理学报 1990; 42 (3): .

Wang Hongqi, Feng Jiadi, Yao Chengyu. Effects of thyroxine and methimazolum on thermosensitive neurons in preoptic/anterior hypothalamic area in rats. Acta Physiol Sin 1990; 42 (3): (in Chinese with English abstract).