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适应性细胞保护作用与胃粘液-碳酸氢盐屏障的关系

汪建英, 王志均

北京医科大学基础医学研究所消化、生殖生理研究室. 北京

摘要

该文观察了由天然或外源性弱刺激引起的适应性细胞保护作用与胃粘液-HCO_(3)~(-)屏障的关系,并分析了它的可能机制。结果表明,胃蛋白酶150单位(溶于0.1 mol/L 盐酸)或20%酒精灌胃,均可引起胃壁结合粘液分泌明显增加,并呈现明显的量效关系,一次处理后,作用可持续60min。这一作用可被消炎痛所阻断;给予外源性 PGE_2又可重新恢复。用醋唑酰胺阻断胃粘膜 HCO_(3)~(-)分泌,则上述两种弱刺激的保护作用均明显减弱。说明天然或外源性弱刺激通过诱发内源性 PGs 的合成和释放,使胃粘膜-HCO_(3)~(-)屏障的机能加强。这可能是它产生适应性细胞保护作用的机制之一。

关键词： 适应性细胞保护作用; 胃粘液; 碳酸氢盐; 胃蛋白酶

The relation between adaptive cytoprotection and gasiric mucus-bicarbonate barrier

Wang Jianying, Wang Chih Chun

Research Laboratory in Physiology of Digestion and Reproduction, Institute of Basic Medical Sciences, Beijing Medical University. Beijing, China

Abstract

This study was performed to determine the relation between the adaptive
cytoprotection observed by natural and exogenous mild irritants and the mitcus-
bicarbonate secretion in the rat's stomach. Mild irritants, pepsin 150 U in 0.lmol/L HCl and 20% ethanol given intragastrically, markedly increased the secretion of mucus in a dose dependent manner. After a single administration, the action lasted 1 h. This increase of mucus secretion could be abolished by indomethacin, an inhibitor of PG synthesis, but could be restored by exogenously applied PGE_(2). Diamox, an inhibitor of carbonic anhydrase, blocked partially the cytoprotection produced by the mild irritants. These results indicate that the natural and exogenous mild irritants could prevent the gastric necrosis, at least partly through the increase of mucus and bicarbonate secretion mediated by endogenous prostaglandins.

Key words: Adaptive cytoprotection;Gastric mucus;Bicarbonate;Pepsin

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引用本文：

汪建英, 王志均. 适应性细胞保护作用与胃粘液-碳酸氢盐屏障的关系[J]. 生理学报 1987; 39 (2): .

Wang Jianying, Wang Chih Chun. The relation between adaptive cytoprotection and gasiric mucus-bicarbonate barrier. Acta Physiol Sin 1987; 39 (2): (in Chinese with English abstract).