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刺激肾神经传入纤维的降压反应与颈动脉窦压力感受性反射的相互作用

潘敬运, 谭立宁, 陈毓槐, 詹澄扬

中山医科大学生理教研室

摘要

在麻醉兔,研究了刺激肾神经传入纤维与颈动脉窦压力感受性反射在减压反射中的相互作用。电刺激肾神经传入纤维引起平均动脉压(MAP)下降,下降程度在一定范围有赖于刺激频率。当颈动脉窦被隔离和主动脉神经切断后,随着颈动脉窦内压逐渐升高,刺激肾神经传入纤维引起的减压反应不断减弱。在45至135mmHg 之间的7个颈动脉窦内压(ISP)水平,刺激肾神经传入纤维,并画出刺激前和刺激时的 ISP-MAP 关系曲线。在颈动脉窦内压为75至105mmHg 之间,刺激肾神经传入纤维显著降低 ISP-MAP 关系曲线的斜率和对ISP 的平均动脉压反应范围。

关键词： 动脉血压; 颈动脉窦压力感受性反射; 肾神经传入纤维

Interaction between renal nerve afferent stimulation-produced depressor response and carotic sinus baroreflex

Pan Jinyun, Tan Lining, Chen Yuhuai, Zhan Chengyang

Department of Physiology, Sun Yat-Sen University of Medical Sciences. Guangzhou, China

Abstract

In anesthetized rabbits the fall in arterial blood pressure was dependent upon
certain voltage and frequency of stimulation of the peripheral end of the renal nerve.In rabbits with vascularly isolated carotid sinuses and aortic nerve cut, the depressor responses to afferent stimulation of renal nerve were progressively diminished as intrasinus pressure (ISP) was elevated stepwise. At seven ISP levels between 45 and 135 mmHg, mean arterial pressure (.MAP) was plotted against ISP to obtain the ISP-MAP relationship before and during afferent stimulation of renal nerve. Afferent stimulation of renal nerve significantly decreased the slope of ISP-MAP relationship between 75 and 105 mmHg ISP and the range of 1SP dependent MAP.These results suggest that(1) the depressor responses to afferent stimulation of renal nerve is modulated by carotid baroreceptor input, varying inversely with the ISP level; and (2) carotid sinus baroreflex sensitivity is greatly decreased by afferent stimulation of renal nerve.

Key words: Arterial blood pressure;Carotid sinus baroreflex;Afferent of renal nerve

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引用本文：

潘敬运, 谭立宁, 陈毓槐, 詹澄扬. 刺激肾神经传入纤维的降压反应与颈动脉窦压力感受性反射的相互作用[J]. 生理学报 1987; 39 (2): .

Pan Jinyun, Tan Lining, Chen Yuhuai, Zhan Chengyang. Interaction between renal nerve afferent stimulation-produced depressor response and carotic sinus baroreflex. Acta Physiol Sin 1987; 39 (2): (in Chinese with English abstract).