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家兔延髓腹侧区内注射吗啡对刺激下丘脑诱发室性期前收缩的抑制作用

郭学勤, 刘宁蔼, 李鹏

上海医科大学生理学教研室. 上海

摘要

家免63只,用乌拉坦(700mg/kg)和氯醛醣(35mg/kg)静脉麻醉,三碘季铵酚制动,在人工呼吸下进行实验。用电刺激下丘脑近中线区的方法诱发定性期前收缩(HVE)。双侧延髓腹侧区内微量注射吗啡(5μg 溶于0.5-1μl 中)可抑制 HVE。在双侧延髓腹侧区微量注射纳洛酬(2μg 溶于0.5-1μl中)能阻断电刺激中缝核尾端或中缝核尾端内微量注射L-谷氨酸钠(50mmol/L, 0.5-1μl)对 HVE 的抑制效应,也能减少或消除刺激腓深神经对 HVE 的抑制作用。

关键词： 延髓腹侧区; 吗啡; 纳洛酮; 室性期前收缩; 中缝核尾端

Inhibitory effect of microinjection of morphine into the ventral medulla on ventricular extrasystoles induced by hypothalamic stimulation in the rabbit

Guo Xueqin, Liu Ningai, Li Peng

Department of Physiology, Shanghai Medical University. Shanghai, China

Abstract

Experiments were carried out on 63 rabbits anesthetized with chloralosc and
urethane. The animals were immobilized with gallamine triethiodide and maintained by artifical ventilation. Bilateral microinjection of morphine (5 fig in 0.5-1#mu#l)into the ventral medulla decreased the number of hypothalamic stimulationinduced ventricular extrasystoles (HVE).Electrical stimulation of the caudal raphe nuclei or microinjection of L-sodium glutamate (50m mol/L,0.5-1#mu#l) into the same area caused a decrease in the number of HVE. However, these effects were diminished following bilateral microinjection of naloxone into the ventral medulla. Inhibition of HVE by electrical stimulation of the deep peroneal nerve (DPN) was less obvious or even abolished by bilateral microinjection of naloxone (2#mu#g in 0.5-1#mu#l) into the ventral medulla. These results suggest that activation of the opiate receptors in the ventral medulla may inhibit HVE, and that the inhibitory effect of DPN stimulation on HVE may be mediated by activation of the opiate receptors in the ventral medulla via activation of the caudal raphe nuclei.

Key words: Ventral medulla;Morphine;Naloxone;Ventricular extrasystoles;Caudal raphenuclei

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引用本文：

郭学勤, 刘宁蔼, 李鹏. 家兔延髓腹侧区内注射吗啡对刺激下丘脑诱发室性期前收缩的抑制作用[J]. 生理学报 1987; 39 (2): .

Guo Xueqin, Liu Ningai, Li Peng. Inhibitory effect of microinjection of morphine into the ventral medulla on ventricular extrasystoles induced by hypothalamic stimulation in the rabbit. Acta Physiol Sin 1987; 39 (2): (in Chinese with English abstract).