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帕金森病大鼠中缝背核5-羟色胺能神经元放电频率和放电形式的变化

褚玉霞, 刘健, 冯洁, 王勇, 张巧俊, 李强

西安交通大学医学院生理学教研室；环境与疾病相关基因教育部重点实验室. 西安 710061

摘要

实验采用玻璃微电极细胞外记录法,观察了帕金森病(Parkinson's disease,PD)大鼠中缝背核(dorsal raphe nucleus,DRN)5-羟色胺(5-hydroxytrypamine,5-HT)能神经元电活动的变化.结果发现,对照组和PD组大鼠DRN中5-HT能神经元的放电频率分别为(1.61±0.56)Hz和(2.61±1.97)Hz,PD组大鼠的放电频率显著高于对照组(P＜0.05)。

关键词： 帕金森病; 中缝背核; 5-羟色胺; 6-羟多巴胺; 电生理学; 大鼠

Changes of discharge rate and pattern of 5-hydroxytrypamine neurons of dorsal raphe nucleus in a rat model of Parkinson's disease

Chu Yuxia, Liu Jian, Feng Jie, Wang Yong, Zhang Qiao Jun, Li Qiang

Department of Physiology, School of Medicine. Xi'an Jiao Tong University；Key Laboratory of Enviorment and Genes Related to Disease. Xi'an 710061, China；Department of Neurology, the Second Hospital, Xi'an Jiao Tong University. Xi'an 710004, China

Abstract

In the present study, changes of the neuronal activity of 5-hydroxytrypamine (5-HT) neurons of dorsal raphe nucleus (DRN) in a rat model of Parkinson's disease (PD) were investigated with glass microelectrode recording. The results showed that the discharge rates of 5-HT neurons in control and PD rats were (1.61±0.56) Hz and (2.61±1.97) Hz, respectively.

Key words: Parkinson's disease;;Dorsal raphe nucleus;5-hydroxytrypamine;6-hydroxydopamine;Electrophysiology

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引用本文：

褚玉霞, 刘健, 冯洁, 王勇, 张巧俊, 李强. 帕金森病大鼠中缝背核5-羟色胺能神经元放电频率和放电形式的变化[J]. 生理学报 2004; 56 (5): .

Chu Yuxia, Liu Jian, Feng Jie, Wang Yong, Zhang Qiao Jun, Li Qiang. Changes of discharge rate and pattern of 5-hydroxytrypamine neurons of dorsal raphe nucleus in a rat model of Parkinson's disease. Acta Physiol Sin 2004; 56 (5): (in Chinese with English abstract).