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急性神经损伤引起脊髓背角C-纤维诱发电位长时程增强

张红梅, 周利君, 胡晓东, 胡能伟, 张彤, 刘先国

中山大学中山医学院生理教研室. 广东, 广州 510089

摘要

神经损伤引起神经病性疼痛,表现为持续性痛超敏和痛觉过敏.目前对神经病性疼痛的机制尚缺乏了解.我们以往的工作表明强直电刺激坐骨神经可引起脊髓背角C-纤维诱发电位的长时程增强(long-term potentiation,LTP),该LTP被认为是病理性疼痛的突触模型。

关键词： 长时程增强; C-纤维; 脊髓背角; 神经损伤; 病理性疼痛

Acute nerve injury induces long-term potentiation of C-fiber evoked field Potentials in spinal dorsal horn of intact rat

Zhang Hongmei, Zhou Lijun, Hu Xiaodong, Hu Nengwei, Zhang Tong, Liu Xianguo

Department of Physiology, Zhangshan Medical School of Sun Yat-Sen University. Guangzhou 510089, China

Abstract

Nerve injury produces a long lasting neuropathic pain, manifested as allodynia, a decrease in pain threshold and hyperalgesia, an increase in response to noxious stimuli. The mechanism underlying the lasting abnormal pain is not well understood. Our previous works have shown that electrical tetanic stimulation of the sciatic nerve induces long-term potentiation (LTP) of C-fiber evoked field potentials in the spinal dorsal horn, which is considered as a synaptic model of pathlogical pain. In the present study we tested if nerve injury, which is proved to produce neuropathic pain, induced the spinal LTP in intact rats.

Key words: Long-term potentiation;C- fiber;Spinal dorsal horn;Nerve injury;Neuropathic pain

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引用本文：

张红梅, 周利君, 胡晓东, 胡能伟, 张彤, 刘先国. 急性神经损伤引起脊髓背角C-纤维诱发电位长时程增强[J]. 生理学报 2004; 56 (5): .

Zhang Hongmei, Zhou Lijun, Hu Xiaodong, Hu Nengwei, Zhang Tong, Liu Xianguo. Acute nerve injury induces long-term potentiation of C-fiber evoked field Potentials in spinal dorsal horn of intact rat. Acta Physiol Sin 2004; 56 (5): (in Chinese with English abstract).