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成瘾性药物对大鼠脑内G蛋白耦联受体激酶5 mRNA和蛋白水平的调控

朱敏, 范学良, 杨伟林, 江燕, 马兰

复旦大学上海医学院药理研究中心, 医学神经生物学国家重点实验室. 上海 200032

摘要

G蛋白耦联受体激酶5(GRK5)在G蛋白耦联受体信号转导中起重要调节作用.该文研究了单次给予成瘾性药物吗啡、海洛因和可卡因对大鼠脑内GRK5 mRNA水平的调控作用,并选取吗啡为代表,观察单次或多次给予吗啡后大鼠脑内GRK5蛋白含量的变化。

关键词： 吗啡; 海洛因; 可卡因; G蛋白耦联受体激酶; 成瘾

Regulation of G protein-coupled receptor kinase 5 mRNA and protein level in rat brain by addictive drugs

Zhu Min, Fan Xueliang, Yang Weilin, Jiang Yan, Ma Lan

Pharmacological Research Center, Shanghai Medical College, Fudan University, State Key Lab of Medical Neurlbiology, Fudan University. Shanghai 200032, China

Abstract

G protein-coupled receptor kinase 5 (GRK5) plans in important role in the regulation of GPCR-transduced signals. Our previous study showed that acute administration of morphine could significantly increase GRK5 m RNA level in the cerebral cortex and hippocampus of the rat brain.

Key words: Morphine;Heroine;Cocaine;G protein-coupled receptor kinase;Addiction

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引用本文：

朱敏, 范学良, 杨伟林, 江燕, 马兰. 成瘾性药物对大鼠脑内G蛋白耦联受体激酶5 mRNA和蛋白水平的调控[J]. 生理学报 2004; 56 (5): .

Zhu Min, Fan Xueliang, Yang Weilin, Jiang Yan, Ma Lan. Regulation of G protein-coupled receptor kinase 5 mRNA and protein level in rat brain by addictive drugs. Acta Physiol Sin 2004; 56 (5): (in Chinese with English abstract).