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增强Na+-Ca2+交换对大鼠心脏的正性变力作用及对哇巴因效应的加强

赵画晨, 武冬梅, 崔香丽, 吴博威

山西医科大学生理教研室. 山西, 太原 030001

摘要

本文采用大鼠乳头肌张力测定及离体心脏灌流技术,研究大鼠心肌Na+-Ca2+交换对乳头肌及离体灌流心脏变力性的影响.采用大鼠特异性Na+-Ca2+交换激动剂E-4031能剂量依赖性地增加大鼠乳头肌的发展张力(P＜0.05,n=6)及离体心脏的心泵功能(P＜0.05,n=4);特异性Na+-Ca2+交换抑制剂KB-R7943具有相反的效应,并可完全消除E-4031引起的正性变力作用。

关键词： 大鼠; 乳头肌; 肌力作用; 钠钙交换; E-4031; KB-R7943; ouabain

Enhancement of sodium-calcium exchange induces positive inotropic action and potentiates ouabain effect in rat hearts

Zhao Huachen, Wu Dongmei, Cui Xiangli, Wu Bowei

Departments of Physiology. Taiyuan, Shangxi 030001, China；Department of Pharmacology ShanXi Medical University. Taiyuan, Shanxi 030001, China

Abstract

To study the inotropic effect of enhanced Na+-Ca2+ exchange in the rat papillary muscles and isolated heart, the developed tension in the rat papillary muscles was measured and the left ventricular functions were assessed in the isolated rat heart. E-4031, a selective activator for Na+-Ca2+ exchange in rats, concentration-dependently increased the developed contractile tension in the rat papillary muscles (P＜0.05, n=6) and the left ventricular functions in the isolated heart; KB-R7943, a selective Na+-Ca2+ exchange inhibitor,exhibited opposite effect.

Key words: Rat;Papillary muscle;Inotropic effect;Na~(+)-Ca~(2+) exchange;E-4031;KB-R7943;ouabain

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引用本文：

赵画晨, 武冬梅, 崔香丽, 吴博威. 增强Na+-Ca2+交换对大鼠心脏的正性变力作用及对哇巴因效应的加强[J]. 生理学报 2004; 56 (4): .

Zhao Huachen, Wu Dongmei, Cui Xiangli, Wu Bowei. Enhancement of sodium-calcium exchange induces positive inotropic action and potentiates ouabain effect in rat hearts. Acta Physiol Sin 2004; 56 (4): (in Chinese with English abstract).