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2Hz与100Hz刺激在诱导大鼠视皮层长持续长时程增强中的不同作用

潘斌, 杨东伟, 韩太真

西安交通大学医学院生理学教研室. 陕西, 西安 710061

摘要

在哺乳动物的视皮层,多种不同参数的刺激可诱导出长时程增强(1ong-term potentiation,LTP)现象.但关于刺激参数与持续时间长于3 h的长持续LTP(1onglasting LTP,L-LTP)之间关系的研究较少.本研究用3周龄的大鼠视皮层脑片标本,在Ⅳ层刺激而在Ⅱ/Ⅲ层记录场电位,待场电位稳定后施加强直刺激诱导LTP,探讨2Hz与100Hz的强直刺激在诱发持续时间长于3h的L-LTP中的作用.

关键词： 长时程增强; 视皮层

Different effects of 2 and 100 Hz tetanus on the expression of long-lasting long-term potentiation in rat visual cortical slices

Pan Bin, Yang Dongwei, Han Taizhen

Department of Physiology, School of Medicine, Xi'an Jiaotong University. Xi'an 710061, Shanxi, China

Abstract

Long-term potentiation (LTP) can be induced by various tetanic parameters in the mammalian visual cortex. However, little researches have been done on the relationship between the expression of the long-lasting LTP (late phase LTP or L-LTP) lasting more than 3 h and the tetanic parameters. In the present study, the effects of 2 Hz and 100 Hz tetanic parameters on L-LTP of the field potentials were recorded from the layer Ⅱ/Ⅲ of the rat visual cortical slices in response to stimulation of the layer Ⅳ.

Key words: Long-term potentiation;Visual cortex

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引用本文：

潘斌, 杨东伟, 韩太真. 2Hz与100Hz刺激在诱导大鼠视皮层长持续长时程增强中的不同作用[J]. 生理学报 2004; 56 (4): .

Pan Bin, Yang Dongwei, Han Taizhen. Different effects of 2 and 100 Hz tetanus on the expression of long-lasting long-term potentiation in rat visual cortical slices. Acta Physiol Sin 2004; 56 (4): (in Chinese with English abstract).