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苍白球γ-氨基丁酸能神经传递及其与神经系统疾病的关系

陈蕾, 容永豪

香港中文大学医学院生理系,香港

摘要

苍白球是基底神经节间接环路的重要核团,在机体运动功能调节中发挥重要作用.近年来,苍白球在基底神经节正常及异常功能调节中的重要性已日渐受到重视.然而,目前对苍白球内各种神经递质系统的功能活动了解较少.GABA是苍白球主要的神经递质.采用电生理记录、免疫组织化学及行为测试等实验方法,人们对大鼠苍白球GABA能神经传递系统的受体分布及功能活动有了新的认识.形态学研究揭示,苍白球存在GABAA受体及其苯二氮卓结合位点和GABAB受体.

关键词： 苍白球; γ-氨基丁酸; 帕金森病; 癫痫

GABAergic neurotransmission in globus pallidus and its involvement inneurologic disorders

Ma Aiqun

Department of Cardiology, the First Hospital, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Xi'an Jiaotong University. Xi'an 710061, China

Abstract

The globus pallidus occupies a critical position in the ‘indirect' pathway of the basal ganglia and, as such, plays an important role in the modulation of movement. In recent years, the importance of the globus pallidus in the normal and malfunctioned basal ganglia is emerging. However, the function and operation of various transmitter systems in this nucleus are largely unknown. GABA is the major neurotransmitter involved in the globus pallidus. By means of electrophysiological recording, immunohistochemistry and behavioral studies, new information on the distribution and functions of the GABAergic neurotransmission in the rat globus pallidus has been generated. Morphological studies revealed the existence of GABAA receptor, including its benzodiazepine binding site, and GABAB receptor in globus pallidus. At subcellular level, GABAA receptors are located at the postsynaptic sites of symmetric synapses (putative GABAergic synapses).

Key words: Globus pallidus;GABA;Parkinson's disease;Seizure

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引用本文：

陈蕾, 容永豪. 苍白球γ-氨基丁酸能神经传递及其与神经系统疾病的关系[J]. 生理学报 2004; 56 (4): .

Ma Aiqun. GABAergic neurotransmission in globus pallidus and its involvement inneurologic disorders. Acta Physiol Sin 2004; 56 (4): (in Chinese with English abstract).