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羟基马桑毒素所致的大鼠海马锥体细胞痫样放电活动

周华, 郑煜, 唐玉红

四川大学华西基础医学与法医学院生理学教研室. 四川, 成都 610041

摘要

本研究采用离体海马脑片电生理研究技术,细胞外记录海马锥体细胞群体锋电位(population spike,PS),观察羟基马桑毒素(tutin)对大鼠海马脑片CA1区锥体细胞电活动的影响,探讨tutin是否具有致痫作用及其致痫机制。

关键词： 癫痫; 羟基马桑毒素; 海马脑片; 痫样放电; NMDA受体; 非NMDA受体

Tutin-induced epileptiform discharge of CA1 pyramidal cells in rat hippocampal slices

Zhou Hua, Zheng Yu, Tangyuong

West China School of Preclinical and Forensic Medicine, Sichuan University. Chengdu 610041, China

Abstract

Previous studies showed that a mixture, Coriaria Lactone (CL), extracted form a traditional Chinese herb Loranthus Parasiticus Mer. had a great excitatory influence on the nervous system, resulting in seizure. But what component in CL causes seizure is unclear. Tutin is a pure chemical component derived form CL. The present experiments were carried out to test if tutin has any epileptogenic action and to preliminarkly study the mechanism underlyint that action in Vitro.

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引用本文：

周华, 郑煜, 唐玉红. 羟基马桑毒素所致的大鼠海马锥体细胞痫样放电活动[J]. 生理学报 2004; 56 (3): .

Zhou Hua, Zheng Yu, Tangyuong. Tutin-induced epileptiform discharge of CA1 pyramidal cells in rat hippocampal slices. Acta Physiol Sin 2004; 56 (3): (in Chinese with English abstract).