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雌性生殖道碳酸氢根分泌机制及其对精子受精能力的影响

周晨曦, 王晓飞, 陈小章

香港中文大学医学院生理系上皮细胞生物学研究中心,香港

摘要

雌性生殖道内微环境对精子获得受精能力所依赖的一系列分子事件起度的碳酸氢根,而且已经证明此阴离子对精子功能(包括精子运动,精子获能,超激活运动以及顶体反应)起重要的作用。该综述详细总结了雌性生殖道内微环境碳酸氢根对精子功能的影响及其分子机制,并探讨子宫内碳酸氢根的分泌机制。同时对碳酸氢根分泌受损可能是女性不育的一个病因提供了最新证据。

关键词： 子宫内膜; 上皮细胞; 分泌; 碳酸氢根; 精子

Bicarbonate secretion by the female reproductive tract and its impact on sperm fertilizing capacity

Zhou Chenxi, Wang Xiaofei, Chen Xiaozhang

Epithelial Cell Biology Research Center,Department of Physiology,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,Hong Kong,China

Abstract

The luminal fluid environment of the female reproductive tract is considered critical for the sperm to undergo a series of molecular events leading to the final acquisition of their fertilizing capacity. It has been shown that the fluid in the female reproductive tract contains high content of HCO_(3)~(-) and it plays an important role in sperm functions including sperm motility, capacitation, hyperactivation and acrosome reaction. This review summarizes the effects of HCO_(3)~(-) on sperm functions occurring in the female reproductive tract and discusses the transport mechanisms involved in mediating uterine HCO_(3)~(-) secretion. New evidence is also presented to show possible cause of female infertility due to defective HCO_(3)~(-) transporting mechanism.

Key words: endometrium;epithelium;Secretion;bicarbonate;spermmatozoa

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引用本文：

周晨曦, 王晓飞, 陈小章. 雌性生殖道碳酸氢根分泌机制及其对精子受精能力的影响[J]. 生理学报 2005; 57 (2): .

Zhou Chenxi, Wang Xiaofei, Chen Xiaozhang. Bicarbonate secretion by the female reproductive tract and its impact on sperm fertilizing capacity. Acta Physiol Sin 2005; 57 (2): (in Chinese with English abstract).