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兔血管外膜对血管重构及收缩功能影响的初步观察

牟华明, 祝之明, 王海燕, 王利娟

第三军医大学大坪医院高血压内分泌科，重庆市高血压病研究所，重庆400042

摘要

研究血管外膜在血管重塑及功能调控中的作用。实验采用在体去除兔颈动脉外膜的方法，于术后即刻、1周及2周取出动脉作组织学、免疫组织化学染色及血管反应性测定。结果显示:(1)去除颈动脉局部外膜对内皮及中层平滑肌无明显损伤;(2)去除外膜后血管平滑肌细胞增殖，并有新生内膜形成;(3)与对照侧比较，去外膜侧血管对去甲肾上腺素的收缩反应在术后即刻及1周时减弱(P < 0. 05)。上述研究结果提示:去除动脉外膜可导致血管内膜增殖及血管平滑肌收缩功能的改变，表明外膜可能参与血管重塑及对血管功能的调控。

关键词： 外膜去除; 内膜增生; 血管反应性

Effect of removal of the adventitia on vascular remodeling and vasoconstriction in rabbits

MU Hua Mng, ZHU Zhi Mug, WANG Hai Yan, WANG Li Juan

Department of Hypertension ； Endocrinology，Chongqing Hypertension Institut Daping Hospital Third Military Medical University，Chongqing 400042

Abstract

The aim of the present stu勿was to investigate the effect of removal of the adventitia on vascular remodeling and vasoconstriction of the carotid artery in New Zealand rabbit .Adventitia of carotid artery was re-
moved mechanically .The histology，morphology and reactivity of the carotid artery was observed妙i m munohistochemistry and measurement of carotid ring tension immediately，1 week and 2 weeks after removal of the adventitia .No damage of intima and media was observed after removing the adventitia.Removal of the adventitia caused a remarkable proliferation of the vascular media and formed the neointima .Compared with the control ring，notepinephrine(NE)一induced vasocontraction in adventitia一denuded carotid artery was significantly reduced immediately and 1 week after the operation(P<0. 05).Adventitia removal promoted the neointima formation and decreased vasoconstriction of the carotid artery，indicating that the adventitia is involved in the regulation of vascular remodeling and vasoconstriction.

Key words: adventitia;carotid artery;rabbit

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引用本文：

牟华明, 祝之明, 王海燕, 王利娟. 兔血管外膜对血管重构及收缩功能影响的初步观察[J]. 生理学报 2003; 55 (3): .

MU Hua Mng, ZHU Zhi Mug, WANG Hai Yan, WANG Li Juan. Effect of removal of the adventitia on vascular remodeling and vasoconstriction in rabbits. Acta Physiol Sin 2003; 55 (3): (in Chinese with English abstract).