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微电泳乙酰胆碱和阿托品对大鼠丘脑束旁核痛敏神经元电活动的影响

张立新, 刘祚延

同济医科大学生理教研室. 武汉 130030

摘要

在30只大鼠上,用多管微电极细胞外记录和离子微电泳方法,观察了乙酰胆碱(ACh)和阿托品对丘脑束旁核(Pf)神经元电活动的影响。结果表明,微电泳ACh可加强痛敏神经元的电活动,并使部分自发放电神经元对伤害性刺激产生反应。阿托品可以阻断ACh的上述作用。微电泳阿托品能减少痛敏神经元的电活动。这些结果提示,在Pf神经元的活动中,ACh可以直接作用于M受体发挥其兴奋作用。

关键词： 乙酰胆碱; 阿托品; 束旁核; 离子电泳; 痛放电

Effects of microiontophoretically applied ADh and atropine on the electric activities of neurons in nucleus parafascicularis of thalamus in rats

Zhang Lixin, Liu Zuoyan

Department of Physiology, Tongjki Medical University. Wuhan 430030, China

Abstract

The effects of acetylcholine (ACh) and atropine on the electric activities of neurons of nucleus parafascicularis thalami (Pf) were observed in anesthetized rats with multimicropiptte technique and iontophoresis. It was found that the spontaneous and pain-induced discharges of the Pf neurons were excited and some of non-nociceptive neurons became sensitive to nociceptive stimulation with microiontophoretically applied ACh，while microiontophoretically applied atropine could diminish the spontaneous and pain-induced discharges of the Pf neurons. The effects of ACh above could be blocked by microiontophoretically applied atropine. The results show that ACh may have excitatory effects on the electric activity of the Pf neurons by M-receptor.

Key words: Acetylcholine;Atropine;Nucleus parafascicularis;Iontophoresis;Nociceptive discharges

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引用本文：

张立新, 刘祚延. 微电泳乙酰胆碱和阿托品对大鼠丘脑束旁核痛敏神经元电活动的影响[J]. 生理学报 1993; 45 (1): .

Zhang Lixin, Liu Zuoyan. Effects of microiontophoretically applied ADh and atropine on the electric activities of neurons in nucleus parafascicularis of thalamus in rats. Acta Physiol Sin 1993; 45 (1): (in Chinese with English abstract).