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血管紧张素--(1--7)的舒血管效应

支建明, 陈蓉芳, 王瑾, 焦向英, 赵荣瑞

上海第二医科大学生理学教研室.上海 200025；第二军医大学卫生毒理学教研室.上海 200433；山西医科大学生理学教研室.山西,太原 030001

摘要

实验采用兔外周动脉离体标本,在预收缩血管后,用血管紧张素[angiotensin--(1--7),Ang--(1--7)]舒张血管,比较Ang--(1--7)对外周各血管床的舒张效应并分析其产生机制。结果显示:(1)Ang--(1--7)可剂量依赖性舒张血管,但舒张作用有所不同;(2)Ang--(1--7)的舒张作用在很大程度上依赖于内皮的NO系统;(3)Ang--(1--7)的舒张血管效应不通过AT_(1)和AT_(2)受体。上述结果提示:Ang--(1--7)可能作用于内皮上的非AT_(1)和AT_(2)受体,通过调节NO释放而起舒血管作用。

关键词： 血管紧张素; 血管舒张; 受体

Comparative studies of vasodilating effects of angiotensin--(1--7) on the different vessels

Zhi Jianming, Chen Rongfang, Wang Jin, Jiao Xiangying, Zhao Rongrui

Department of Physiology,Shanghai Second Medical University.Shanghai 200025；China；Department of Physiology,Shanxi Medical University.Taiyuan 030001,Shanxi

Abstract

The purpose of this study was to compare the vasodilating effects of angiotensin-(1-7) [Ang-(1-7)] on the different vessels and to clarify its mechanisms by using relaxing responses of preconstricted vascular rings. The results showed: (1) Ang-(1-7) dosedependently induced vasorelaxation in all the vessels studied. However, there is apparent heterogeneity in the responsiveness of vessels from different origin. (2) The Ang-(1-7)-induced vasorelaxation was endothelium dependent and largely mediated by NO system. (3) The vasodilator action of Ang-(1-7) was not mediated by AT_(1) or AT_(2) receptor subtypes. It is suggested that the Ang-(1-7)-induced vasorelaxation is endothelium dependent by some other unclarified angiotensin receptor subtypes and is largely mediated by NO system.

Key words: angiotensin;vasorelaxation;receptor

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引用本文：

支建明, 陈蓉芳, 王瑾, 焦向英, 赵荣瑞. 血管紧张素--(1--7)的舒血管效应[J]. 生理学报 2004; 56 (6): .

Zhi Jianming, Chen Rongfang, Wang Jin, Jiao Xiangying, Zhao Rongrui. Comparative studies of vasodilating effects of angiotensin--(1--7) on the different vessels. Acta Physiol Sin 2004; 56 (6): (in Chinese with English abstract).