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辣椒素对颈动脉窦压力感受性反射的易化作用

张浩, 刘宜先, 武宇明, 王升, 何瑞荣

河北医科大学基础医学研究所生理室.河北,石家庄 050017

摘要

在30只隔离灌流颈动脉窦区的麻醉大鼠,观察了辣椒素(CAP)对颈动脉窦压力感受性反射的影响。结果显示(1)以CAP(1#mu#mol/L)隔离灌流大鼠左侧颈动脉窦区时,颈动脉窦压力感受性机能曲线向左下方移位,曲线最大斜率(PS)由0.34±0.01增至0.42±0.01(P<0.01),反射性血压下降幅度(RD)由36.51±1.26增至45.01±0.72 mmHg(P<0.01)。阈压、平衡压和饱和压分别从70.43±2.09、95.5±1.71和177.60±1.37 mmHg下降至52.86±2.80、87.00±1.58、163.55±2.12 mmHg(P<0.01)。其中PS和RD的变化呈明显的剂量依赖性。(2)用香草酸受体亚型(VR_(1))阻断剂钌红(ruthenium red, 100 #mu#mol/L)预处理后,CAP的上述反射效应即被阻断。(2)先给予K_(ATP)通道阻断剂格列苯脲(glibenclamide, 20 #mu#mol/L)也取消了CAP对压力感受性反射的影响。结果表明,CAP对大鼠颈动脉窦压力感受性反射有易化作用,此作用拟与VR_(1)介导的K_(ATP)通道开放有关。

Capsaicin facilitates carotid sinus baroreflex in anesthetized rats

Zhang Hao, Liu Yixian, Wu Yuming, Wang Sheng, He Ruirong

Department of Physiology,Institute of Basic Medicine,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

The effects of capsaicin (CAP) on the carotid sinus baroreflex were studied in 30 anaesthetized rats with perfused isolated carotid sinus. On the basis of the rsults, it is concluded that CAP facilitates the carotid baroreflex, an effect of which may be resulted from the opening of K_(ATP) channels mediated by VR_(1).

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引用本文：

张浩, 刘宜先, 武宇明, 王升, 何瑞荣. 辣椒素对颈动脉窦压力感受性反射的易化作用[J]. 生理学报 2004; 56 (2): .

Zhang Hao, Liu Yixian, Wu Yuming, Wang Sheng, He Ruirong. Capsaicin facilitates carotid sinus baroreflex in anesthetized rats. Acta Physiol Sin 2004; 56 (2): (in Chinese with English abstract).