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小鼠血浆TNF-#alpha#、NO、NOS水平与脑不对称的关系

付清玲, 李康生

汕头大学医学院微生物学与免疫学教研室.广东,汕头 515031

摘要

各组间血浆TNF-#alpha#和NO、NOS水平的变化:正常生理组NO水平为双利组高于左利组(P<0.05);LPS刺激后双利组和右利组血浆TNF-#alpha#水平高于左利组(P<0.05),NO水平为双利组高于右利组(P<0.01)和左利组(P<0.05),NOS水平在三组小鼠间无明显差别。血浆TNF-#alpha#、NO、NOS与右利分有一定的相关关系,各项指标随右利分的变化趋势多为双利>右利和左利,形成一以双利分段(右利分为21-29)为高峰的弓形向上的曲线,随右利分的增加或减少曲线向两侧延伸和下降。结果提示,脑不对称小鼠单核/巨噬细胞功能存在差异。脑不对称对免疫功能的影响程度与右利分有关,各免疫指标随右利分的变化趋势多为一以双利分段为高峰的弓形向上的曲线。

关键词： 脑不对称; 免疫调控; 肿瘤坏死因子α; 一氧化氮; 一氧化氮合酶; 巨噬细胞

The correlations between plasma TNF-#alpha#, NO, NOS levels and brain lateralization in mice

Fu Qingling, Li Kangsheng

Department of Microbiology and Immunology,Shantou University Medical College.Shantou 515031,Guangdong

Abstract

The results showed that (1) in the normal mice, ambidextrous mice had higher NO levels compared with left-pawed mice (P<0.05). After the injection of LPS, plasma level of TNF-#alpha# was lower in left-pawed mice compared with those of the right-pawed and ambidextrousmice; plasma level of NO was higher in ambidextrous mice compared with those of the right-(P<0.01) and left-pawed (P<0.05) ones, and there was no significant difference in the plasma levels of NOS among ambidextrous, right- and left-pawed mice. (2) Immune parameters were correlated with the RPE scores. The shape of the curve describing this relation was similar to a parabola. In general, the levels of TNF-#alpha#, NO, NOS rose along with increase of RPE if the scores were in the score range of left-pawed mice. After that, they reached a peak if the scores were in the score range of ambidextrous mice. Then they declined along with the increase of RPE if the scores were in the score range of right-pawed mice. In conclusion, plasma levels of TNF-#alpha#, NO and NOS were associated with brain lateralization, suggesting that the activaties of Mo/M#PHI# were influenced by brain lateralization, and that the immune parameters were correlated with the RPE scores.

Key words: Brain lateralization;Immunomodulation;Tumor necrosis factor-#alpha#;Nitric oxide;nitric oxide synthase;Macrophage

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引用本文：

付清玲, 李康生. 小鼠血浆TNF-#alpha#、NO、NOS水平与脑不对称的关系[J]. 生理学报 2002; 54 (6): .

Fu Qingling, Li Kangsheng. The correlations between plasma TNF-#alpha#, NO, NOS levels and brain lateralization in mice. Acta Physiol Sin 2002; 54 (6): (in Chinese with English abstract).