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男性吸烟者体重对烟碱引起的生热作用和儿茶酚释放的影响

Walker J F, Kane C J

贝拉明大学心肺科学研究室.美国,肯塔基州 40205

摘要

正常体重组在吸低烟碱烟后和超重组不论在吸低烟碱烟或高烟碱烟后,安静时能量消耗(REE)和血浆儿茶酚胺均无明显改变。而在正常体重组中,吸高烟碱烟后血浆去甲肾上腺素浓度升高,同时REE增加7.2%;如果将血浆烟碱水平作为一个共变量进行分析,则吸烟后血浆去甲肾上腺素浓度和REE的改变也不明显,表明吸烟后的生热效应是因血浆烟碱浓度升高而引起的。体重对烟碱的生热效应能发生影响,在超重的吸烟者中烟碱的生热效应减弱。由此推测,正常体重的吸烟者在戒烟后,由于不再有吸烟引起的耗能生热,可能导致体重增加。

关键词： 烟碱的生热效应; 交感神经系统; 身体构成

Effects of body mass on nicotine--induced thermogenesis and catecholamine release in male smokers

Walker J F, Kane C J

Cardiopulmonary Science Program, Bellarmine University.Louisville, KY 40205

Abstract

There was no thermic effect of nicotine or catecholamine response after smoking llow yield cigarettes in both groups, nor after smoking high yield cigarettes in the overweight group. In contrast, REE increased 7.2%, which was accompanied by an increase in plasma norepinephrine release, after smoking high yield cigarettes in the normal weight group. Controlling plasma nicotine level ablated these increases. In conclusion, body mass interacts with the thermic effect of nicrotine and neuroendocrine function in male smokers. Smoking-induced increase in the plasma nicotine level accounts for the observed responses, which are blunted in overweight smokers. This finding may have implications for potential weight gain following smoking cessation by normal weight individuals, related to lost smoking-induced thermogenesis.

Key words: Thermic effect of nicotine;Sympathetic nervous system;Body composition

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引用本文：

Walker J F, Kane C J. 男性吸烟者体重对烟碱引起的生热作用和儿茶酚释放的影响[J]. 生理学报 2002; 54 (5): .

Walker J F, Kane C J. Effects of body mass on nicotine--induced thermogenesis and catecholamine release in male smokers. Acta Physiol Sin 2002; 54 (5): (in Chinese with English abstract).