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全身放射损伤对皮肤伤口成纤维细胞参与组织修复能力的影响

屈纪富, 程天民, 许霖水, 史春梦, 冉新泽

第三军医大学全军复合伤研究所.重庆 400038；第三军医大学生化教研室.重庆 400038

摘要

在去除全身因素和局部因素,特别是创伤局部细胞因子和细胞外基质对成纤维细胞的反馈作用后,放创复合伤组伤口成纤维细胞增殖力、贴壁力和粘附力均显著弱于单纯创伤组,而成纤维细胞的凋亡率则显著增加。结果表明,全身放射损伤对伤口成纤维细胞有直接损伤作用,使其参与组织修复能力显著受抑,这是合并全身放射损伤时创伤难愈的重要原因。

关键词： 成纤维细胞; 组织修复; 创伤愈合; 全身放射损伤

Effects of total body irradiation injury on the participation of dermal fibroblasts in tissue repair

Qu Jifu, Cheng Tianmin, Xu Linshui, Shi Chunmeng, Ran Xinze

Institute of Combined Injury of PLA,Third Military Medical University.Chongqing 400038；China

Abstract

The results showed that the abilities of proliferation, attachment and adhesion of fibroblasts isolated from wounds combined with TBI injury significantly decreased as compared with those of simple incision injury, nevertheless, apoptotic ratio of fibroblasts isolated from wounds combined with TBI injury increased significantly. These data suggest that TBI injury may cause direct damaging effects on fibroblasts in wounds, which might be one of the dominant reasons for impairment of wound healing when it is combined with TBI injury.

Key words: Fibroblasts;Tissue repair;Wound healing;Total body irradiation injury

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引用本文：

屈纪富, 程天民, 许霖水, 史春梦, 冉新泽. 全身放射损伤对皮肤伤口成纤维细胞参与组织修复能力的影响[J]. 生理学报 2002; 54 (5): .

Qu Jifu, Cheng Tianmin, Xu Linshui, Shi Chunmeng, Ran Xinze. Effects of total body irradiation injury on the participation of dermal fibroblasts in tissue repair. Acta Physiol Sin 2002; 54 (5): (in Chinese with English abstract).