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体力运动减缓慢性应激对海马的损伤作用

马强, 王静, 刘洪涛, 晁福寰

军事医学科学院卫生学环境医学研究所.天津 300050

摘要

为探讨体力运动对慢性应激引起的海马损伤的影响,在大鼠整体水平检测海马长时程增强(LTP)和血浆糖皮质激素(GCs)水平。结果发现,8周的跑轮运动会明显减缓随后21d的慢性束缚应激对海马齿状回(DG)LTP的抑制,且可维持血浆GCs水平正常。结果提示,长期体力运动对海马有保护作用,可减缓慢性应激引起的损伤。

关键词： 运动; 应激; 海马; 长时程增强; 糖皮质激素

Attenuation of chronic stress-induced hippocampal damages following physical exercise

Ma Qiang, Wang Jing, Liu Hongtao, Chao Fuhuan

Institute of Health and Environmental Medicine,Academy of Military Medical Sciences.Tianjin 300050

Abstract

The long-term potentiation (LTP) in the hippocampal dentate gyrus and the plasma glucocorticoids level were observed in rats to study the effects of physical exercise on chronic stress-induced hippocampal damages. Eight-week spontaneous wheel running exercise could attenuate the suppression of LTP induced by 21-day restraint stress, and maintain the normal plasma glucocorticoids levels. It is suggested that long-term physical exercise may protect the hippocampus from stress-induced damages.

Key words: Exercise;;;;

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引用本文：

马强, 王静, 刘洪涛, 晁福寰. 体力运动减缓慢性应激对海马的损伤作用[J]. 生理学报 2002; 54 (5): .

Ma Qiang, Wang Jing, Liu Hongtao, Chao Fuhuan. Attenuation of chronic stress-induced hippocampal damages following physical exercise. Acta Physiol Sin 2002; 54 (5): (in Chinese with English abstract).