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慢性镉负荷雄性大鼠的睾丸及生殖内分泌功能活动

陈龙, 任文华, 朱善良, 高伟, 周娟, 蒋英子, 谷宇

南京师范大学生命科学学院.江苏,南京 210097；南京医科大学江苏省应用毒理重点实验室.江苏,南京 210029

摘要

选择健康SD雄性成年大鼠60只,随机分成对照组(C组)、镉负荷中剂量组(M组)和镉负荷高剂量组(H组),每天分别饲喂含镉0、5、10mg/kg的大鼠全价饲料,连续6周,研究了镉负荷对大鼠睾丸及生殖内分泌功能活动的影响。在整个实验期内,M和H组大鼠睾丸组织中的镉含量极明显上升,锌含量稍有下降,与对照组差异不显著;血浆镉、锌含量虽分别表现稍有升高和下降,但与对照组比较无明显差异;H组睾丸精子头计数和每日精子生成量在镉负荷第3周极显著下降,第6周时,M和H组均极明显低于对照组;在整个实验期内,H组大鼠ALP活性明显低于C组;LDH-X活性在M和H组大鼠均极明显低于C组;M和H组血浆T水平下降,均低于或显著低于C组;3组间的FSH和LH水平无明显差异。

关键词： 镉; 睾丸; 生殖; 内分泌; 大鼠

Effects of chronic cadmium loading on the testis and endocrine function of reproduction in male rats

Chen Long, Ren Wenhua, Zhu Shanliang, Gao Wei, Zhou Juan, Jiang Yingzi, Gu Yu

College of Life Science,Nanjing Normal University.Nanjing 210097,Jiangsu；China

Abstract

Sixty healthy Sprague-Dawley male rats were used and divided randomly into control group (group C), cadmium loading group with medium dose (group M) and cadmium loading group with high dose (group H). Groups C, M and H were orally dosed daily with 0, 5 and 10mg/kg of cadmium for over 6 weeks. Effects of cadmium loading on testis and endocrine function of reproduction in male rats were studied. The results showed that the gradual accumulation of cadmium in testis tissue induced by chronic cadmium loading results in changes in some enzyme activity, a decrease in sperm production, and defect of endocrine function activity in the testis.

Key words: Cadmium;Testis;Reproduction;Endocrinology;Rats

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引用本文：

陈龙, 任文华, 朱善良, 高伟, 周娟, 蒋英子, 谷宇. 慢性镉负荷雄性大鼠的睾丸及生殖内分泌功能活动[J]. 生理学报 2002; 54 (3): .

Chen Long, Ren Wenhua, Zhu Shanliang, Gao Wei, Zhou Juan, Jiang Yingzi, Gu Yu. Effects of chronic cadmium loading on the testis and endocrine function of reproduction in male rats. Acta Physiol Sin 2002; 54 (3): (in Chinese with English abstract).