过刊浏览

免疫细胞分泌研究进展

娄雪林, 何立铭, 龚非力, 于晓, 徐涛, 周专

华中科学技术大学生命科学学院生物物理与生物化学研究所.湖北,武汉 430074；华中科学技术大学免疫学研究所.湖北,武汉 430074；中科院神经科学研究所.上海 200031

摘要

细胞分泌活动涉及一系列复杂的分子活动和信号转导过程,它是许多重要生命活动如神经递质的释放、内分泌激素分泌、蛋白质转运等的基础。故而有关细胞分泌活动的研究近年在国际上形成一个新的热点。有关免疫细胞中细胞因子的分泌机制研究得较少,将膜电容测量、电化学测量、光学测量、胞内信号分子光解等近年发展起来的生物物理方法引入免疫学领域,对研究免疫细胞的分泌调控和信号转导意义重大。

关键词： 分泌; 实时检测; 细胞因子; SNARE; 融合孔道

A brief introduction to the secretion mechanism in immunocytes

Lou Xuelin, He Liming, Gong Feili, Yu Xiao, Xu Tao, Zhou Zhuan

Institute of Biophysics and Biochemistry,Huazhong University of Science and Technology.Wuhan 430074,Hubei；China；Institute of Neuroscience.Shanghai 200031

Abstract

Exocytosis is a vital function of many cell types including neuron, endocrine cell and immunocyte. Secretion in immunocytes involves a complex process of signal transduction, in which many factors still remain unknown. In the last 10 years, this area has become an international hot spot of investigation, resulting in many break-through progresses. This progress was made possible by combined efforts in molecular biology, cell biology and biophysics. This review focuses on notable new knowledge and some new techniques in functional study of secretion in immunocytes.

Key words: Bodily secretions;Real-time;Cell factor;Soluble NSF attachment protein receptors(SNARE);Fusion pore

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

娄雪林, 何立铭, 龚非力, 于晓, 徐涛, 周专. 免疫细胞分泌研究进展[J]. 生理学报 2002; 54 (3): .

Lou Xuelin, He Liming, Gong Feili, Yu Xiao, Xu Tao, Zhou Zhuan. A brief introduction to the secretion mechanism in immunocytes. Acta Physiol Sin 2002; 54 (3): (in Chinese with English abstract).