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肾性高血压大鼠延髓尾端神经元型一氧化氮合酶表达的改变

王晶, 陈志江, 罗灿乔, 潘敬运

福建医科大学生理学教研室.福建,福州 350004；福建省立医院外科.福建,福州 350001；中山医科大学病理学教研室.广东,广州 510089；中山医科大学生理学教研室.广东,广州 510089

摘要

肾性高血压大鼠延髓尾端这两个区域的nNOS的表达均增加,说明高血压时L-Arg-NO通路活性增强。NO的前体L-Arg能增强nNOS的表达,nNOS抑制剂L-NAME则降低nNOS的表达。以上两个区域nNOS表达变化的特点在肾性高血压4周和7周的动物相同,肾性高血压7周的nNOS表达和4周比较,未见明显差异。

关键词： 延髓腹面降压区; 延髓尾端加压区; 神经元型一氧化氮合酶; L精氨酸; N硝基L精氨酸甲酯

The expression of neuronal nitric oxide synthase in caudal medulla of two-kidney one clip Goldblatt hypertension rat

Wang Jing, Chen Zhijiang, Luo Canqiao, Pan Jingyun

Department of Physiology,Fujian Medical University.Fuzhou 350004,Fujian；China；Departments of Pathology,Sun Yat-Sen University of Medical Sciences.Guangzhou 510089,Guangdong

Abstract

The results showed that: (1)only a few neuronal nitric oxide synthase (nNOS) positive neurones were found in caudal medulla, including the depressor area of the ventral surface of medulla oblongata (VSMd) and the caudal pressor area (CPA) of the sham operated animals. The number of nNOS positive neurons in caudal medulla was significantly increased in 2K1C Goldblatt hypertension rats at 4 and 7 weeks. (2)The number of nNOS positive neurons in VSMd and CPA were 2K1C+Arg>2K1C>2K1C+NAME>sham. (3)L-Arg enhanced the expression of nNOS whereas L-NAME inhibited the expression of nNOS in caudal medulla. (4)The character of nNOS expression was similar in Goldblatt hypertension rats at 4 weeks with that of the rats at 7 weeks.

Key words: Depressor area of the ventral surface of medulla oblongata;Caudal pressor area;Neuronal nitric oxide synthase;L-arginine;N(G)-nitro-L-arginine methyl ester

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引用本文：

王晶, 陈志江, 罗灿乔, 潘敬运. 肾性高血压大鼠延髓尾端神经元型一氧化氮合酶表达的改变[J]. 生理学报 2002; 54 (2): .

Wang Jing, Chen Zhijiang, Luo Canqiao, Pan Jingyun. The expression of neuronal nitric oxide synthase in caudal medulla of two-kidney one clip Goldblatt hypertension rat. Acta Physiol Sin 2002; 54 (2): (in Chinese with English abstract).