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CCK-8对内毒素休克大鼠肺脏细胞因子的抑制效应

孟爱宏, 凌亦凌, 赵晓云, 张君岚, 王秋红

河北医科大学病理生理教研室.河北,石家庄 050017

摘要

CCK-8可改善LPS引起的大鼠MAP的下降。与对照组相比,LPS可显著增加血清和肺脏TNF-#alpha#、IL-1#beta#和IL-6含量;CCK-8可显著抑制LPS诱导的血清和肺脏TNF-#alpha#、IL-1#beta#和IL-6的增加。CCK-8可增加ES大鼠肺脏磷酸化p38 MAPK的表达。

关键词： 缩胆囊素; 内毒素; 细胞因子; 肺脏; p38丝裂素活化蛋白激酶

Inhibitory effect of cholecystokinin-octapeptide on production of cytokines in the lung of endotoxic shock rats

Meng Aihong, Ling Yiling, Zhao Xiaoyun, Zhang Junlan, Wang Qiuhong

Department of Pathophysiology,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

The results showed that CCK-8 alleviated LPS-induced decreased in MAP of rats; compared with the control, LPS elevated the levels of TNF-#alpha#, IL-1#beta# and IL-6 in serum and lung significantly, while CCK-8 significantly inhibited the LPS-induced increases in TNF-#alpha#, IL-1#beta# and IL-6 in serum and lung. The activation of p38 MAPK in the lung of ES rats was enhanced by CCK-8 pretreatment.

Key words: Cholecystokininr octapeptide;Endotoxin;Cytokine;Lung;p38 mitogen-activated protein kinase

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引用本文：

孟爱宏, 凌亦凌, 赵晓云, 张君岚, 王秋红. CCK-8对内毒素休克大鼠肺脏细胞因子的抑制效应[J]. 生理学报 2002; 54 (2): .

Meng Aihong, Ling Yiling, Zhao Xiaoyun, Zhang Junlan, Wang Qiuhong. Inhibitory effect of cholecystokinin-octapeptide on production of cytokines in the lung of endotoxic shock rats. Acta Physiol Sin 2002; 54 (2): (in Chinese with English abstract).