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ATP-敏感钾通道和内源性腺苷参与刺激蓝斑引起的脊髓抗痛作用

韩葆芬, 张策, 祁金顺, 乔健天

山西医科大学神经生物学研究室.山西,太原 030001

摘要

(1)蓝斑刺激在脊髓背角中抑制痛信号的上传,要有ATP-敏感钾通道的激活和内源性腺苷的释放为中介;(2)ATP-敏感钾通道的激活发生在腺苷的释放之前。

关键词： 蓝斑刺激; 束旁核伤害感受神经元; 鞘内注入; ATP敏感钾通道; 腺苷

ATP-sensitive potassium channels and endogenous adenosine are involved in spinal antinociception produced by locus coeruleus stimulation

Han Baofen, Zhang Ce, Qi Jinshun, Qiao Jiantian

Department of Neurobiology,Shanxi Medical University.Taiyuan 030001,Shanxi

Abstract

These results suggest that: (1)K~(+)_(ATP) channels and endogenous adenosine may be involved in the mediation of spinal antinociception induced by descending adrenergic fibers originating from the LC; and (2) the opening of K~(+)_(ATP) channels precedes the release of adenosine in the cascade of mediation.

Key words: Locus coeruleus stimulation;Parafascicular nociceptive neurons;Intrathecal injection;ATP-sensitive potassium channel;Adenosine

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引用本文：

韩葆芬, 张策, 祁金顺, 乔健天. ATP-敏感钾通道和内源性腺苷参与刺激蓝斑引起的脊髓抗痛作用[J]. 生理学报 2002; 54 (2): .

Han Baofen, Zhang Ce, Qi Jinshun, Qiao Jiantian. ATP-sensitive potassium channels and endogenous adenosine are involved in spinal antinociception produced by locus coeruleus stimulation. Acta Physiol Sin 2002; 54 (2): (in Chinese with English abstract).