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刺激室旁核及加压素对大鼠胃缺血-再灌注损伤的保护作用

张建福, 张咏梅, 阎长栋, 周秀萍, 祁友键

徐州医学院生理学教研室.江苏,徐州 221002；徐州医学院神经生物学教研室.江苏,徐州 221002

摘要

PVN及AVP对大鼠GI-RI具有保护作用;PVN的这种作用可能是因电或化学刺激后,激活了其中的加压素能神经元,经其下行投射纤维释放AVP作用于NTS神经元的AVP-V_(1)受体,并通过迷走和交感神经介导,从而影响GI-RI;而似与PVN-垂体通路关系不大。

关键词： 室旁核; 精氨酸加压素; 孤束核; 脑垂体; 胃缺血再灌注损伤

Protective effects of paraventricular nucleus stimulation and vasopressin on gastric ischemia-reperfusion injury in rats

Zhang Jianfu, Zhang Yongmei, Yan Changdong, Zhou Xiuping, Qi Youjian

Department of Physiology,Xuzhou Medical College.Xuzhou 221002,Jiangsu；China

Abstract

These results suggest that the PVN and AVP participate in the regulation of GI-RI and play an important role in protection against GI-RI. This protective effect of PVN on GI-RI might be mediated by activation of AVP-ergic neurons in the PVN, which release AVP from the descending projection fibers and activate the AVP-V_(1) receptors on the NTS neurons. The vagus and sympathetic nerves are involved in the efferent pathway exerting their effects on GI-RI. Hypophysis does not seem to be involved in the protective effect of PVN stimulation.

Key words: Paraventricular nucleus(PVN);Arginine-vasopressin(AVP);Nucleus tractus solitarius(NTS);Hypophysis;Gastric ischemia-reperfusion injury(GI-RI)

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引用本文：

张建福, 张咏梅, 阎长栋, 周秀萍, 祁友键. 刺激室旁核及加压素对大鼠胃缺血-再灌注损伤的保护作用[J]. 生理学报 2002; 54 (2): .

Zhang Jianfu, Zhang Yongmei, Yan Changdong, Zhou Xiuping, Qi Youjian. Protective effects of paraventricular nucleus stimulation and vasopressin on gastric ischemia-reperfusion injury in rats. Acta Physiol Sin 2002; 54 (2): (in Chinese with English abstract).