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三叉神经对去运动神经支配面肌肌萎缩的影响

骆泉丰, 李秀娥, 龚祖埙

中科院上海生物化学与细胞生物学研究所,上海生命科学研究院.上海 200031；青岛市市立医院急症科.山东,青岛 266011

摘要

用组织化学、电镜以及肌球蛋白和肌动蛋白电泳分析等方法分析了在单纯性面神经切断和三叉神经、面神经同时切断后面肌萎缩的病理改变--肌纤维的显微结构改变以及面肌收缩蛋白质在手术后不同时期的降解变化。实验证明,面部肌肉在不同的神经切断情况下其病理改变不同,正常的三叉神经支配可以延缓面瘫后肌肉蛋白质的降解,减少胶原纤维结缔组织的增生,较好地保护肌纤维的显微结构,延缓和减轻去运动神经支配面肌肌萎缩。该研究结果可以为临床治疗面瘫提供一定的理论指导。

关键词： 肌肉; 感觉神经; 去神经; 肌萎缩

Effect of trigeminus nerve on facialis-denervated facial muscle atrophy

Luo Quanfeng, Li Xiue, Gong Zuxun

Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences.Shanghai 200031；China

Abstract

In the present study we made out an animal model on rabbit whose trigeminus and facialis nerves were simultaneously or only the latter one was severed. The pathological changes in facial muscle atrophy under different nerve injuries were investigated. The degeneration of contractile proteins of upper lip muscle-myosin and actin was observed. In addition, we also examined the ultrastructural changes in the muscle atrophy in the two above-mentioned nerve injury cases. We observed that the intact trigeminus nerve could delay and lighten the atrophy of facialis-denervated facial muscle and attenuate the degeneration of myosin and actin, as well as decrease the increment of collagen and maintain the ultrastructure of the thick and thin muscle filaments. These results may provide the possibility of improvement of clinical treatment for facial muscle palsy.

Key words: Muscle;Sensory nerve;Denervation;Muscular atrophy

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引用本文：

骆泉丰, 李秀娥, 龚祖埙. 三叉神经对去运动神经支配面肌肌萎缩的影响[J]. 生理学报 2002; 54 (2): .

Luo Quanfeng, Li Xiue, Gong Zuxun. Effect of trigeminus nerve on facialis-denervated facial muscle atrophy. Acta Physiol Sin 2002; 54 (2): (in Chinese with English abstract).