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脂多糖诱导小鼠脏器中胞间粘附分子-1的表达

闫文生, 阚文宏, 黄巧冰, 姜勇, 王士雯, 赵克森

第一军医大学全军休克微循环重点实验室.广东,广州 510515；解放军总医院老年心血管病研究所.北京 100853

摘要

在LPS诱导的内毒素休克小鼠的多种脏器中ICAM-1蛋白和mRNA表达显著增加。脏器间ICAM-1表达上调的差异可能带来内毒素休克时脏器的不同易伤性,抑制ICAM-1的表达可能与内毒素休克的防治有重要的意义。

关键词： 内毒素休克; 脂多糖; 胞间粘附分子-1

Expression of intercellular adhesion molecule-1 in different organs of the mice with endotoxic shock induced by lipopolysaccharide

Yan Wensheng, Kan Wenhong, Huang Qiaobing, Jiang Yong, Wang Shiwen, Zhao Kesen

Key Laboratory of Shock and Microcirculation of PLA,The First Military Medical University.Guangzhou 510515,Guangdong；China

Abstract

Results highlight that LPS can up-regulate ICAM-1 protein and mRNA expression in different tissues of the mice with endotoxic shock. The difference in ICAM-1 expression among the organs may lead to different sensitivity of organ damage in endotoxic shock. This suggests that inhibition of ICAM-1 expression may be a useful principle for prevention and treatment of endotoxic shock.

Key words: Endotoxic shock;Lipopolysaccharide;Intercellular adhesion molecule-1

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引用本文：

闫文生, 阚文宏, 黄巧冰, 姜勇, 王士雯, 赵克森. 脂多糖诱导小鼠脏器中胞间粘附分子-1的表达[J]. 生理学报 2002; 54 (1): .

Yan Wensheng, Kan Wenhong, Huang Qiaobing, Jiang Yong, Wang Shiwen, Zhao Kesen. Expression of intercellular adhesion molecule-1 in different organs of the mice with endotoxic shock induced by lipopolysaccharide. Acta Physiol Sin 2002; 54 (1): (in Chinese with English abstract).