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褪黑素对大鼠空间学习记忆的影响及其机制研究

冯寅, 张烈雄, 晁东满

复旦大学医学院神经生物学教研室.上海 200032；华东师范大学生命科学学院生理学教研室.上海 200062；复旦大学医学院生理学教研室.上海 200032

摘要

褪黑素对大鼠的空间学习记忆能力及海马CA1区LTP均有明显的抑制作用,两者相关;东莨菪碱不能阻断褪黑素对海马CA1区LTP的抑制作用,而荷包牡丹碱可以阻断褪黑素对LTP的抑制,提示褪黑素的作用可能不是由胆碱能系统所介导,而是通过GABA能系统介导。

关键词： 褪黑素; 空间学习记忆; 长时程增强; 东莨菪碱; 荷包牡丹碱

Role of melatonin in spatial learning and memory in rats and its mechanism

Feng Yin, Zhang Liexiong, Chao Dongman

Department of Neurobiology,Medical Center of Fudan University.Shanghai 200032；China

Abstract

Our results showed that application of melatonin in rats significantly inhibited not only spatial learning and memory, but also LTP in CA1 area. Furthermore, the results indicates that the inhibition of LTP by melatonin may not be mediated by cholinergic system, but may be through the modulation of GABAergic system.

Key words: Melatonin;Spatial learning and memory;Long-term potentiation;Scopolamine;Bicuculline

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引用本文：

冯寅, 张烈雄, 晁东满. 褪黑素对大鼠空间学习记忆的影响及其机制研究[J]. 生理学报 2002; 54 (1): .

Feng Yin, Zhang Liexiong, Chao Dongman. Role of melatonin in spatial learning and memory in rats and its mechanism. Acta Physiol Sin 2002; 54 (1): (in Chinese with English abstract).