过刊浏览

异丙酚抑制炎性痛大鼠脊髓NOS神经元的c-fos表达

颜明, 张励才, 戴体俊, 曾因明, 段世明

徐州医学院附属医院麻醉科.江苏,徐州 221006；徐州医学院麻醉学系.江苏,徐州 221002

摘要

福尔马林痛刺激后,刺激侧脊髓背角出现大量Fos免疫样阳性神经元,其中部分为FLI/NOS双标记神经元;痛刺激之前或之后给予异丙酚,背角各层FLI神经元和FLI/NOS双标记神经元的数量均显著减少(P<0.05或P<0.01);单纯腹腔注射异丙酚或生理盐水,脊髓未见或偶见FLI神经元。

关键词： 异丙酚; 脊髓; 免疫组织化学; 组织化学; Fos; NOS

Propofol depresses c-fos expression of NOS neurons in the spinal cord of rats with inflammatory pain

Yan Ming, Zhang Licai, Dai Tijun, Zeng Yinming, Duan Shiming

Department of Anesthesiology,Affiliated Hospital of Xuzhou Medical College.Xuzhou 221006,Jiangsu；China

Abstract

The results suggest that the antinociceptive function of propofol is possibly involved in the depression of the NOS neurons in the spinal cord.

Key words: Propofol;Spinal cord;Immunohistoche mistiy;Histoche mistry;Fos;NOS

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

颜明, 张励才, 戴体俊, 曾因明, 段世明. 异丙酚抑制炎性痛大鼠脊髓NOS神经元的c-fos表达[J]. 生理学报 2002; 54 (1): .

Yan Ming, Zhang Licai, Dai Tijun, Zeng Yinming, Duan Shiming. Propofol depresses c-fos expression of NOS neurons in the spinal cord of rats with inflammatory pain. Acta Physiol Sin 2002; 54 (1): (in Chinese with English abstract).