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延髓头端腹外侧区一氧化氮与慢性心力衰竭大鼠心交感传入反射的关系

朱国庆, 高兴亚, 张枫, 王玮

南京医科大学生理学系.江苏,南京 210029；内布拉斯加大学医学院生理和生物物理系.奥马哈市,NE 68198-4575,美国

摘要

为观察延髓头端腹外侧区(RVLM)一氧化氮(NO)在慢性心力衰竭(CHF)大鼠增强的心交感传入反射(CSAR)中的作用,实验在去压力感受器神经支配的结扎冠状动脉诱发的CHF大鼠和假手术SD大鼠进行,记录电刺激心交感传入神经中枢端前后的血压和肾交感神经活动(RSNA)变化以评价CSAR。结果显示:(1)CHF大鼠的CSAR显著增强;(2)RVLM微量注射NO合酶(NOS)抑制剂MeTC增强对照组大鼠的CSAR,但对CHF大鼠的CSAR无显著影响;(3)RVLM微量注射NO供体S-nitroso-N-acetyl-penicillamine(SNAP)抑制CHF大鼠增强的CSAR;(4)S-methyl-L-thiocitruline(MeTC)仅增强对照组大鼠基础水平的RSNA,而SNAP抑制对照组和CHF大鼠基础水平的RSNA。结果表明,RVLM中内源性NO的减少是导致CHF大鼠CSAR增强的重要机制之一。。

关键词： β-adrenergic receptors; heart; signal transduction

Reduced nitric oxide in the rostral ventrolateral medulla enhances cardiac sympathetic afferent reflex in rats with chronic heart failure

Zhu Guoqing, Gao Xingya, Zhang Feng, Wang Wei

Department of Physiology,Nanjing Medical University.Nanjing 210029,Jiangsu；USA

Abstract

It was observed that (1) the responses of RSNA to stimulation were enhanced in rats with CHF; (2) MeTC (80 nmol) potentiated the responses of RSNA to stimulation in sham rats but not in rats with CHF; (3) SNAP (50 nmol) depressed the enhanced RSNA response to stimulation in CHF rats but had no effect in sham rats; and (4) MeTC increased the baseline RSNA and MAP only in sham rats, but SNAP inhibited the baseline RSNA and MAP in both sham and CHF rats. These results indicate that reductance of NO in the RVLM is involved in the augmentation of CSAR in CHF rats.

Key words: β肾上腺素受体;心脏;信号传导

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引用本文：

朱国庆, 高兴亚, 张枫, 王玮. 延髓头端腹外侧区一氧化氮与慢性心力衰竭大鼠心交感传入反射的关系[J]. 生理学报 2004; 56 (1): .

Zhu Guoqing, Gao Xingya, Zhang Feng, Wang Wei. Reduced nitric oxide in the rostral ventrolateral medulla enhances cardiac sympathetic afferent reflex in rats with chronic heart failure. Acta Physiol Sin 2004; 56 (1): (in Chinese with English abstract).