过刊浏览

肠上皮快速复原过程中的细胞信号传递:多胺和K~(+)通道的影响

汪建英

马里兰大学医学院外科学和病理学系.美国

摘要

胃肠道粘膜上皮细胞具有重要的屏障作用,可以保护次上皮组织抵御一系列的有害物质,包括过敏原、病毒以及微生物病原体。粘膜损伤后的修复有赖于上皮细胞对信号网络的调节,而这一网络系统控制着基因的表达、细胞的存活、迁移及增殖。近几年的研究结果显示,在胃肠道粘膜的修复中,多胺起到关键作用;且细胞多胺的调控是众多信号传递路径的焦点。简要综述了多胺在肠粘膜上皮快速复原中的功能和机制,特别是对K~(+)通道活性的影响。

关键词： 肠上皮; 细胞内钙离子; 粘膜损伤; 膜电位; 细胞迁移; 钾通道

Cellular signaling in rapid intestinal epithelial restitution: implication of polyamines and K~(+) channels

Wang Jianying

Department of Surgery and Pathology,University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center.Baltimore, Maryland, USA

Abstract

Epithelial cells line the gastrointestinal (GI) mucosa and form an important barrier that protects the subepithelial tissue against a wide array of oxious substances, allergens, viruses, and luminal microbial pathogens. Restoration of mucosal integrity following injury requires epithelial cell decisions that regulate signaling networks controlling gene expression, survival, migration, and proliferation. Over the past few years, polyamines have been shown to play a critical role in GI mucosal repair, and the control of cellular polyamines is a central convergence point for the multiple signaling pathways. Both the function of polyamines in rapid intestinal mucosal epithelial restitution and the underlying mechanism, especially the implication of K~(+) channel activity, are the subject of this mini-review article.

Key words: Intestinal epithelium;IntraceUular Ca~（2+）;Mucosal injury;membrane potential;Cell migration;K~~(+) channels

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

汪建英. 肠上皮快速复原过程中的细胞信号传递:多胺和K~(+)通道的影响[J]. 生理学报 2003; 55 (4): .

Wang Jianying. Cellular signaling in rapid intestinal epithelial restitution: implication of polyamines and K~(+) channels. Acta Physiol Sin 2003; 55 (4): (in Chinese with English abstract).