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NMDA受体参与小鼠的前额扣带回的神经突触传递

Liauw J, 王过渡, 卓敏

华盛顿大学医学院麻醉系,解剖及神经生物系,精神病学系,华盛顿大学痛觉中心.圣路易,密苏里州 63110,美国

摘要

作者在离体的前额扣带回脑片上进行电生理记录,发现NMDA受体参与前额扣带回的突触传递。在重复刺激或近于生理性温度时,NMDA受体传递的反应更为明显。该文直接显示了NMDA受体参与前额扣带回的突触传递,并提示NMDA受体在前额扣带回中起着调节神经元兴奋的重要作用。

关键词： 谷氨酸; 前额扣带回; 痛觉; 小鼠

NMDA receptors contribute to synaptic transmission in anterior cingulate cortex of adult mice

Liauw J, Wang Guodu, Zhuo Min

Department of Anesthesiology,Anatomy & Neurobiology and Psychiatry,Washington University Pain Center,Washington University, St. Louis, MO63110,USA

Abstract

Here we show that NMDA receptors contribute to synaptic responses in the anterior cingulate cortex (ACC), a region important for cognitive and other brain functions. The contribution of NMDA receptors became more prominent when synapses are stimulated at higher frequencies. Furthermore, at temperatures more close to physiological brain temperatures, more NMDA receptor mediated responses were recorded as compared to the room temperature. These data suggest a new function for NMDA receptors in the ACC as important postsynaptic receptors involved in synaptic transmission, in particular when cells are firing at high frequencies.

Key words: Glutamate;Anterior eingulate cortex;（ACC） pain;Mouse

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引用本文：

Liauw J, 王过渡, 卓敏. NMDA受体参与小鼠的前额扣带回的神经突触传递[J]. 生理学报 2003; 55 (4): .

Liauw J, Wang Guodu, Zhuo Min. NMDA receptors contribute to synaptic transmission in anterior cingulate cortex of adult mice. Acta Physiol Sin 2003; 55 (4): (in Chinese with English abstract).