过刊浏览

小鼠脑内甘氨酸含量在缺氧预适应中的变化

刘宏雁, 吕国蔚, 王维忠

白求恩医科大学药理室.吉林,长春 130021；首都医科大学神经生物学系.北京 100054；白求恩医科大学第三临床医院.吉林,长春 130031

摘要

在小鼠重复缺氧预适应过程中,用HPLC方法,测定其全脑与不同脑区中的甘氨酸含量。结果表明,随着动物对低氧耐受性的增高,其全脑、间脑,特别是海马、脑干中的甘氨酸含量升高。结果提示,甘氨酸作为抑制性递质对低氧预适应的形成具有正面影响。

关键词： 甘氨酸; 缺氧耐受性; 缺氧预适应

Changes in glycine content in mouse brain during hypoxic preconditioning

Liu Hongyan, Lu Guowei, Wang Weizhong

Department of Pharmacology,Bethune Medical University.Changchun 130021,Jilin；China

Abstract

Glycine content of the whole btain and subregions was measured by high pressure liquid chromatography (HPLC) in mice during their repetitive exposures to hypoxia. The content sof glycine in whole brain, diencephalon, and hippocampus and brain stem was significantly increased as the animals^ tolerance to hypoxia was increased. The results suggest that glycine, as an inhibitory neurotransmitter in the brain, may positively contribute to the development of hypoxic preconditioning.

Key words: Glycine;Hypoxic tolerance;Hypoxic preconditioning

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

刘宏雁, 吕国蔚, 王维忠. 小鼠脑内甘氨酸含量在缺氧预适应中的变化[J]. 生理学报 2001; 53 (6): .

Liu Hongyan, Lu Guowei, Wang Weizhong. Changes in glycine content in mouse brain during hypoxic preconditioning. Acta Physiol Sin 2001; 53 (6): (in Chinese with English abstract).